Conformational analyses are presented of several pharmacologically important norditerpenoid alkaloids (NDAs), in crystal and solution states. Crystal data 8 NDAs (4 free bases 4 salts) were obtained, which crassicauline A, aconitine HCl, methyllycaconitine HClO4 reported for the first time. 1D/2D NMR spectroscopies 7 (5 2 recorded comprehensively. conformations described with a revised cyclohex...

Two-dimensional 1H-15N HMBC NMR spectra of the well-known anticonvulsant carbamazepine dissolved in different organic solvents, recorded on an spectrometer prove existence hidden conformers saturated solutions. Obtained conformer distribution arises due to presence solid phase solution. A weak influence ring currents was revealed for molecular conformations a solution, which provides simple app...

RNA structure heterogeneity is a major challenge when querying structures with chemical probing. We introduce DRACO, an algorithm for the deconvolution of coexisting conformations from mutational profiling experiments. Analysis SARS-CoV-2 genome using dimethyl sulfate sequencing (DMS-MaPseq) and identifies multiple regions that fold into two mutually exclusive conformations, including conserved...