Sequence-specific DNA detection is important in various biomedical applications such as gene expression profiling, disease diagnosis and treatment, drug discovery and forensic analysis. Here we report a gold nanoparticle-based method that allows DNA detection and quantification and is capable of single nucleotide polymorphism (SNP) discrimination. The precise quantification of single-stranded D...

In the early phases of a geomagnetic storm, the low and mid-latitude ionosphere are greatly perturbed. Large SAPS electric fields map earthward from the perturbed ring current overlapping and eroding the outer plasmasphere and mid-latitude ionosphere, drawing out extended plumes of storm enhanced density (SED). We use combined satellite and ground-based observations to investigate the degree of...

The synthesis, structure, and electronic spectra of a series of DNA hairpins possessing two perylenediimide (PDI) base pair surrogates are reported. The PDI chromophores are located in opposite strands of the hairpin base pair domain opposite abasic sites and are either adjacent to each other or separated by a variable number of AT or GC base pairs. Molecular modeling of the conjugate having ad...

Chiral bifunctional sulfamides were found to be highly efficient organocatalysts for the conjugate addition of aldehydes to nitroolefins in the presence of base additives.

In this paper a theory of conjugate approximations is developed which provides a fundamental basis for most methods of continuous piecewise approximation. It is shown that for a given finite set of base functions used in an approximation there corresponds another set of conjugate functions which play a significant role in approximate methods of analysis. In the case of finite-element approximat...

A unified approach is presented for the synthesis of continuous-time fractional orthogonal bases including Laguerre-like, Kautz-like and the GeneralizedOrthogonal-Basis-like (GOB-like) bases. They extend the definitions of their rational counterpart to fractional differentiation orders. Modes can either be chosen to be real or by pairs complex conjugate. Completeness of fractional Laguerre-like...

Current Gibbs sampling schemes in mixture of Dirichlet process (MDP) models are restricted to using \conjugate" base measures which allow analytic evaluation of the transition probabilities when resampling con gurations, or alternatively need to rely on approximate numeric evaluations of some transition probabilities. Implementation of Gibbs sampling in more general MDP models is an open and im...

Synthesis of a BQQ-neomycin conjugate is reported. The conjugate combines two ligands, one known to intercalate triplexes (BQQ) and another known to bind in the triplex groove (neomycin). The conjugate stabilizes T.A.T, as well as mixed base DNA triplex, better than neomycin, BQQ, or a combination of both. The conjugate selectively stabilizes the triplex (in the presence of physiological salt c...