the effect of boundary conditions on the solution of the inverse problem of identifying the geometry and location of a cavity inside an elastic solid body using displacement measurements obtained from a tension test is investigated. the boundary elements method (bem) coupled with the genetic algorithm (ga) and the conjugate gradient method (cgm) are implemented in this identification problem. a...

This manuscript presents the synthesis and structural characterisation of novel biodegradable polymeric controlled-release systems of pesticides with potentially higher resistance to weather conditions in comparison to conventional forms of pesticides. Two methods for the preparation of pesticide-oligomer conjugates using the transesterification reaction were developed. The first method of obta...

abstract background: high temperatures have destructive effects on cancer cells by damaging proteins and structures within cells. gold nanoparticles (aunps) can act as drug delivery vehicles, especially for cancer therapy. due to the selective intake of asparagine molecules into malignant cells, aunps were coated with asparagine; and ccrf-cem human t-cell leukemia cells were treated with the ne...

A method is presented for covalently bonding Haemophilus influenzae type b capsular polysaccharide (HIB Ps) to several proteins. The method is efficient and relies upon the use of adipic dihydrazide as a spacer between the capsular polysaccharide and the carrier protein. In contrast to the poor immunogenicity of the purified HIB Ps in mice and rabbits, the HIB Ps-protein conjugates induced seru...

Five new bifunctional conjugates of pyropheophorbide a with 17-substituted testosterone, dihydrotestosterone and epitestosterone differing in the length linker (1 � 5) two complex 6 7 (containing three functional units: a, 17?-substituted lipophylic hexadecyl chain, connected L-lysine joining block) were synthesized. Mutual influence steroidal macrocyclic fragments 7) was established by analysi...

An artificial neural networks (ANNs) approach is presented for the prediction of effective thermal conductivity of porous systems filled with different liquids. ANN models are based on feedforward backpropagation network with training functions: LevenbergeMarquardt (LM), conjugate gradient with FletchereReeves updates (CGF), one-step secant (OSS), conjugates gradient with PowelleBeale restarts ...

A robust and highly reproducible capillary isoelectric focusing (cIEF) method for the evaluation of charge heterogeneity of monoclonal antibody (mAb) pharmaceutical which contains covalently bound antitumor compounds was developed using a combination of commercially available dimethylpolysiloxane-coated capillary and carrier ampholyte. In order to optimize major analytical parameters for robust...