نتایج جستجو برای: connexin36
تعداد نتایج: 161 فیلتر نتایج به سال:
myoclonic epilepsy Association of the connexin36 gene with juvenile service Email alerting top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at the
Identifiable mixed electrical and chemical synapses on Mauthner cells, the club endings, have historically provided a window for the study of electrical transmission in vertebrates because of their accessibility for both physiological and ultrastructural characterization. Recent data show that electrical transmission at these terminals is mediated by connexin35 (Cx35), the fish ortholog of the ...
To examine the functions of electrical synapses in the transmission of signals from rod photoreceptors to ganglion cells, we generated connexin36 knockout mice. Reporter expression indicated that connexin36 was present in multiple retinal neurons including rod photoreceptors, cone bipolar cells, and AII amacrine cells. Disruption of electrical synapses between adjacent AIIs and between AIIs and...
Rod signals reach ganglion cells via at least five pathways. A new study in this issue of Neuron shows that all pathways from rods to ON-type ganglion cells require connexin36. This is the first physiological demonstration in mammals that a well-defined neural circuit requires a gap junction as an obligatory transmission step.
background: gabaergic interneurons in the hippocampal ca1 area are mutually communicated by gap junctions (gjs) composed of connexin36 (cx36). we examined the role of cx36 in ca1 in manifestation of kindled seizures and hippocampal kindling in rats. methods: quinine, as the specific blocker of cx36, was injected into ca1, and kindled seizures severity was examined 10 min afterward. moreover, qu...
Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling? Interneuron gap junctions enhance synchrony of gamma oscillations (25-70 Hz) in isolated interneuron networks and also in networks containing both interneurons and principal cells, as shown in mice with a kn...
The olivo-cerebellar system is crucial for smooth and well timed execution of movements based on sensory and proprioceptive cues. The inferior olive (IO) plays a pivotal role in this process by synchronizing its activity across neurons internally through connexin36 gap junctions and providing a timing and/or learning signal to the cerebellum. Even though synchrony achieved through electrical co...
A striking example of neuronal synchronization occurs in the mammalian main olfactory bulb where mitral cells that project to the same glomerular unit display highly synchronized spike activity. In this issue of Neuron, Christie et al. use mice deficient for the gap junction protein connexin36 (Cx36) to demonstrate that Cx36-mediated electrical coupling underlies such synchrony.
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