As scientists who are also clinicians, we should approach research work and clinical therapy with an objective attitude, bearing in mind that there are two sides to every theory. In particular, we hope the reader realizes the pros and cons of each situation. We already knew that the patients in the hospital might improve faster with more family contact, but family in the intensive care unit cou...

INTRODUCTION Coagulase-negative staphylococci (CoNS) are a group of micro-organisms that are increasingly implicated as a cause of significant infection and the leading cause of bloodstream infection (BSI). One important predictor of true BSI is the isolation of CoNS from multiple blood cultures, presuming that the isolates represent the same species. Thus the objective of this study was to det...

Infections caused by commensal organisms by changing to infectious life style generate much challenge to the current treatment strategies. Coagulase Negative Staphylococci (CoNS) are one of them, with their coexisting biofilm forming and multiple antibiotic resistance properties form important agents of nosocomial infection. To evaluate species distribution, biofilm formation, and antibiogram, ...

Background: Coagulase negative staphylococci (CoNS), once considered as non-pathogenic commensal of skin and mucus membrane have emerged as important pathogen. Aim: The aim of this study is to determine species of CoNS and antimicrobial susceptibility pattern of species obtained from various clinical specimens. Materials and Methods: A total of 79 Coagulase negative staphylococci (CoNS) isolate...

BACKGROUND Coagulase negative Staphylococci (CoNS) are one of the most common bacteria found on human skin and on mucous membranes as a component of normal flora. The presence of CoNS in clinical specimens is frequently associated with an infectious aetiology or contamination. OBJECTIVES We aimed to evaluate CoNS species distribution and susceptibility patterns in specimens obtained from clin...

OBJECTIVE To study late onset systemic infections with coagulase negative staphylococci. METHODS Prospective longitudinal study of coagulase negative staphylococcal infection in 18 Australasian neonatal nurseries. RESULTS From 1991 to 2000 inclusive, there were 1281 cases of coagulase negative staphylococcal (CoNS) sepsis, comprising 57.1% of all late onset infections. The male/female ratio...

OBJECTIVES Methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) is caused by expression of the low-affinity penicillin-binding protein (PBP) 2a encoded by the mecA gene. This gene is carried on the staphylococcal cassette chromosome mec (SCCmec) of which several types and subtypes have been described. CoNS and S. aureus share SCCmec types and it has been s...

Although coagulase-negative staphylococci (CoNS) is a frequent cause of prosthetic valve endocarditis, native valve endocarditis (NVE) caused by CoNS is not commonly seen. Its high mortality is well known; however, there are no systematic reports published in Japan. We herein report the cases of two Japanese patients with CoNS NVE who were admitted to our hospital located in Tokyo and conduct l...