The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocytic pits to promote their fission. However, the dynamin mechanism is still debated because constriction is necessary but not sufficient for fission. Here, we show that fission occurs at the interface between the dynamin coat and the uncoated membrane. At this location, the considerable change in membrane ...

abstract a 2.5 year old girl is presented with both hands constriction bands leading to distal amputations and the rare deformity of shoulder duplication in the right side accompanying constriction skin marking over the affected shoulder. the cephalomedial scapula articulated with the clavicle and the caudolateral scapula articulated with humeral head. the most important physical finding which ...

background: compressive neuropathy of median nerve is relatively common but development of an hourglass like constriction is a rare phenomenon. the purpose of this study is to show morphologic changes of median nerve in advances carpal tunnel syndrome. methods: eighty patients with thenar atrophy, anesthesia and paresthesia of first, second and third finger and severe changes of emg‑ncv were ch...

Abstract Cells migrate collectively to form tissues and organs during morphogenesis. Contact inhibition of locomotion (CIL) drives collective migration by inhibiting lamellipodial protrusions at cell–cell contacts promoting polarization the leading edge. Here, we report a CIL-related cell behavior myotubes that lack protrusions, but instead use filopodia move as cohesive cluster in formin-depen...

Counterpropagating (upstream) chiral neutral edge modes, which were predicted to be present in hole-conjugate states, were observed recently in a variety of fractional quantum Hall states (ν=2/3, ν=3/5, ν=8/3, and ν=5/2), by measuring the charge noise that resulted after partitioning the neutral mode by a constriction (denoted, as N→C). Particularly noticeable was the observation of such modes ...

Many morphogenetic movements during development require the formation of transient intermediates called rosettes. Within rosettes, cells are polarized with apical ends constricted towards the rosette center and nuclei basally displaced. Whereas the polarity and cytoskeletal machinery establishing these structures has been extensively studied, the extracellular cues and intracellular signaling c...

The complexities of how prosodic structure, both at the phrasal and syllable levels, shapes speech production have begun to be illuminated through studies of articulatory behavior. The present study contributes to an understanding of prosodic signatures on articulation by examining the joint effects of phrasal and syllable position on the production of consonants. Articulatory kinematic data we...

one of the locations of renal artery atherosclerosis is at the orifice of the renal artery, therefore thestructure of this orifice was assessed in 6 normal, adult male dogs by light microscopy (lm) andtransmission electron microscopy (tem). for the lm study, processed tissues were embedded in paraffinand sectioned serially into 6-μm thickness. sections were stained with orcein. for the tem stud...

Amniotic Band Syndrome is a sporadic congenital disorder that may result in constriction bands, amputation and multiple craniofacial, visceral and body wall defects. Its incidence is estimated at approximately 1:5000 to 1:10,000 pregnancies. Band formation most frequently affects the distal segments, including the hand. We report a case of constriction amniotic bands involving the trunk.