Copper amine oxidases are important enzymes, which contribute to the regulation of mono- and polyamine levels. Each monomer contains one Cu(II) ion and 2,4,5-trihydroxyphenylalanine (TPQ) as cofactors. They catalyze the oxidative deamination of primary amines to aldehydes with a ping-pong mechanism consisting of a transamination. The mechanism is followed by the transfer of two electrons to mol...

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Symmetry is an intrinsic property of homo-oligomers. Amine oxidases are multidomain homodimeric enzymes that contain one catalytic site per subunit, and share a high homology degree. In this paper, we investigated, by fluorescence spectroscopy measurements, the conformational dynamics resiliency in solutions two amine oxidases, from lentil seedlings, Euphorbia characias latex, which crystallogr...

Introduction Copper amine oxidases are ubiquitous metalloenzymes. Their function in prokaryotes and lower eukaryotes is to utilise amines as a source for carbon and nitrogen. In higher eukaryotes, their roles are less well understood, but have been linked with cell signalling, growth and development, and cell death. Despite this apparent diversity, their fundamental role is to catalyse the oxid...