Abstract Estrogen deficiency during post-menopausal osteoporosis leads to osteoclastogenesis and bone loss. Increased pro-osteoclastogenic signalling (RANKL/OPG) by osteocytes occurs following estrogen withdrawal (EW) is associated with impaired focal adhesions (FAs) a disrupted actin cytoskeleton. RANKL production mediated Hedgehog in osteocytes, pathway the primary cilium, ciliary structure t...

Abstract IL-9 is produced by Th9 cells and classically known as a growth-promoting cytokine. Although protumorigenic functions of are described in T cell lymphoma, recently, we others have reported anti-tumor activities melanoma mediated mast CD8+ cells. However, involvement invasive breast cervical cancer remains unexplored. In this study, demonstrate IL-9–dependent inhibition metastasis both ...

Aims: To clarify the effect of DM type 2 on bladder contractility in diabetic patients. Methods: Patients (60 adult male patients) with lower urinary tract symptoms (LUTS) underwent a detailed urodynamic investigation. Urodynamic findings were classified as cystopathy [DC, characterized by impaired sensation, increased post-void residual urine (PVR) and capacity decreased contractility], detrus...

objective: several studies have shown that chichorium intybus l. (c. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. the aim of the present study was to investigate the effect of aqueous extra...

Abstract Introduction The RhoA/ROCK calcium-sensitizing pathway plays a role in clitoral contractility, and therefore we deemed interesting to investigate its involvement the vagina. Objective aim of this study was sex steroid regulation vagina contractility through pathway, using validated animal model. Methods Ovariectomized Sprague-Dawley rats (OVX) were treated with 17β-estradiol (E2), test...