Iron-copper interactions were described decades ago; however, molecular mechanisms linking the two essential minerals remain largely undefined. Investigations in humans and other mammals noted that copper levels increase in the intestinal mucosa, liver and blood during iron deficiency, tissues all important for iron homeostasis. The current study was undertaken to test the hypothesis that dieta...

Iron and copper are essential trace metals, actively absorbed from the proximal gut in a regulated fashion. Depletion of either metal can lead to anemia. In the gut, copper deficiency can affect iron absorption through modulating the activity of hephaestin - a multi-copper oxidase required for optimal iron export from enterocytes. How systemic copper status regulates iron absorption is unknown....

1. Our data indicate that the effectiveness of whole liver in the treatment of nutritional anemia in rats induced by a milk diet is directly proportional to its available iron and copper content. The other constituents in liver are not needed for maximum hemoglobin regeneration on a diet of milk, iron, copper, and manganese. 2. Commercial preparations of liver products with iron or iron and cop...

Increases in serum and liver copper content are noted during iron deficiency in mammals, suggesting that copper-dependent processes participate during iron deprivation. One point of intersection between the 2 metals is the liver-derived, multicopper ferroxidase ceruloplasmin (Cp) that is important for iron release from certain tissues. The current study sought to explore Cp expression and activ...

The unicellular green alga Chlamydomonas reinhardtii is a valuable model for studying metal metabolism in a photosynthetic background. A search of the Chlamydomonas expressed sequence tag database led to the identification of several components that form a copper-dependent iron assimilation pathway related to the high-affinity iron uptake pathway defined originally for Saccharomyces cerevisiae....

Green synthesis of nanoparticles utilizing plant extract has shown enormous advantages over the methods synthesis. are generally synthesized using metal atoms like silver, iron, copper, zinc, and containing reducible phytoconstituents alkaloids, flavonoids, tannins, etc. Several Iron reported extracts. have a greater advantage small size, affordable cost stability, or having some biomedical app...

In this study, the concentrations of heavy metals (Ca, Zn, Cu, Fe, Mn, Ni) in thesediment of Shavoor River in Khuzestan Province in Iran has been investigated. After the library studies and field studies, six samples of water and sediment were taken from the river in order to evaluate heavy metal pollution in sediments. To determine the geochemical phases of metals in sediment samples the 5-ste...

The aim of this study was to investigate the effects of iron and copper on bovine oocyte maturation, preimplantation embryo development and apoptosis of blastocysts. The concentrations of iron in the culture media were 0 (control), 0.45, 0.81, 1.96 and 3.26 mg/l, and the concentrations of copper were 0 (control), 0.093, 0.27, 0.46 and 0.68 mg/l. The changes in the iron (1.96 mg/l) and copper co...

Copper and iron are essential elements for cellular growth. Although bacteria have to overcome limitations of these metals by affine and selective uptake, excessive amounts of both metals are toxic for the cells. Here we investigated the influences of copper stress on iron homeostasis in Bacillus subtilis, and we present evidence that copper excess leads to imbalances of intracellular iron meta...

The paper presents a surface mounted permanent magnet synchronous machine (SMPMSM) with distributed windings. The main focus of the paper is to provide a new calculation method of electric machine losses, including copper losses and iron losses at load. This method based on the separation of injected current in d-q axes and the developed iron loss models expressing the dependence between the fl...