Walker-Smith, J. A., and Blomfield, J. (1973). Archives of Disease in Childhood, 48, 476. Wilson's disease or chronic copper poisoning? The case history is given of a child who presented at 14 months with ascites and was found to have severe micronodular cirrhosis with biochemical evidence of Wilson's disease, but in view of the severity of the pathology and early age of presentation, the possi...

in this study we investigated histopathological changes of mice ovarian tissues following long-term administration of copper sulfate and induction of chronic copper poisoning. the study comprised of three different groups of twenty one mice as follows: the first group (group 100) which treated by gavage with copper sulfate at a dose of 100 mg kg-1 for 5 weeks. the second group (group 200), whic...

Copper sulphate ingestion (accidental or deliberate) is a rare form of poisoning usually limited to the Indian subcontinent. Though the rates are on the decline, it is essential that physicians are aware of its lethal complications and management strategies. The main complications of copper sulphate ingestion include intravascular haemolysis, methaemoglobinaemia, acute kidney injury and rhabdom...

In the Mehler reaction, a Hill reaction utilizing molecular oxygen as the electron acceptor, rates of net oxygen uptake are stimulated by added manganous ions. Both whole cell photosynthesis and the Mehler reaction are inhibited by copper. Copper inhibition of the Mehler reaction can be reversed by manganese salts. Glutathione. which alone has no effect on Mehler reaction rates, enhances the ef...

Copper sulphate is a compound prepared by the action of sulphuric acid on copper II. Copper sulphate is widely used asfungicide, herbicide and for photography. In a human being, it can lead to anemia. Medical literature is lacking regarding accidental or suicidal poisoning cases of copper sulphate in Pakistan. We present a case of accidental ingestion of copper sulphate resulting in severe acut...

background copper (cu) is an essential trace element involved in normal reproduction but its overexposure may produce some detrimental effects. the aim of this study was to investigate the effects of copper sulfate poisoning on morphometery of mice ovarian structures and probable intracellular changes. methods thirty mature female mice were randomly allocated to control and two treatment groups...

Pathological findings and liver and kidney analyses confirmed that cattle had died of chronic copper poisoning on a farm in the north-eastern Transvaal. This is the first known published record of chronic copper intoxication of cattle in southern Africa. An epidemiological study revealed that a source of copper was air pollution which could have arisen from a nearby copper smelting unit. Buffal...

Zinc therapy has replaced penicillamine as first-line therapy for Wilson's disease. New guidelines reflect the paradigm shift in treatment that has occurred in recent years. In the old paradigm, Wilson's disease was seen as genetic disorder associated with the accumulation of copper in the liver and in other organs once the liver had become overloaded with copper. When left untreated, the disea...