Tyrosinemia type II (Richner-Hanhart syndrome) is a rare autosomal recessive disease with deficiency of tyrosine aminotransferase and subsequently increasing level of serum tyrosine. We report the case of a 2-year-old girl who was referred due to bilateral corneal lesions. Slit-lamp examination showed small granular white deposits arranged in a dendritic pattern in the superficial central corne...

Macular corneal dystrophy is an inherited corneal disease characterized by corneal opacities resulting from intra- and extracellular deposits within the corneal stroma. Several monoclonal antibodies developed against antigens of corneal fibroblasts were screened for their reactivity with these abnormal deposits in corneas with macular dystrophy using an indirect peroxidase-conjugated immunostai...

Secondary corneal calcification involving the full thickness of the stroma is a rare potential complication of severe dry eye conditions, recurrent corneal ulcerations, chronic ocular inflammation, or multiple surgical procedures. We describe on a patient with unusual, hitherto unreported calcareous degeneration of the corneal stroma after topical steroid-phosphate therapy for chronic keratocon...

PURPOSE To quantify the morphological alterations in corneal nerve fibers and cells in patients with pseudoexfoliation syndrome (PEX) and their relationship with the presence of hyperreflective endothelial deposits observed using in vivo confocal microscopy. METHODS One eye each of 37 patients with PEX and 20 age-matched healthy control subjects was evaluated by in vivo corneal confocal micro...

AIMS To evaluate corneal electrolysis as a treatment for recurrent diffuse corneal opacities at the host-graft interface of the stroma or at the subepithelial region in two types of granular corneal dystrophy (GCD). METHODS Recurrence developed at the host-graft interface of the stroma after lamellar keratoplasty in a patient with Avellino corneal dystrophy (ACD). At surgery, the deep aspect ...

The abundant documentation of small mammals in the Italian peninsula, collected over recent years, furnishes a detailed biochronological sequence mainly from the Late Pliocene onwards. An updated stratigraphic framework is here presented, based on the European small mammal biozonation. The Early Villanyian is characterized by Mimomys hassiacus, M. stehlini, and, later, poorly documented M. polo...

1989 (T= 3 83, p<<0 001). The numbers of partners in the month before interview also significantly increased from a mean of 2-1 (median 1) to 2-2 (1) (T=2-03, p<OO5). More importantly from the point of view of HIV transmission the mean number of penetrative sexual partners in the previous year rose from 2-2 (median 1) to 2 5 (1) and in the previous month from 0 5 (0) to 0-6 (0), though neither ...

SUMMARY We report a case of previously unsuspected myeloma, presenting with cornea verticillata due to intracorneal paraprotein deposition. HISTORY An 85-year-old female presented via her optician with a 4-month history of cloudy vision. She had undergone an uneventful bilateral phacoemulsification surgery 7 years earlier. Extensive spiraling corneal epithelial opacification was noted on slit...

Identification of sea-level proxies is important for reconstruction of past sea-level variation. Methods for reconstructing Holocene relative sea-level curves are crucial for quantification of the impact of Greenland ice thickness variation on global sea level and vertical land movement. Arctic beach ridges constitute important potential archives of sea-level variation. However, their surface m...