purpose: to report the confocal scan features in a case with clinical diagnosis of meesmann corneal dystrophy (mcd). case report: a 17-year-old female with recurrent episodes of corneal erosion and a clinical diagnosis of mcd underwent in vivo confocal scanning of both corneas. the confocal scan features included hyporeflective round-shaped areas measuring 6.8 to 41.4 mm within the superficial ...

The regenerated epithelium derived from limbal epithelium was histologically and biochemically compared with epithelia regenerated from corneal and bulbar conjunctival epithelia. The histologic results indicated that regenerated epithelium of limbal origin increased in thickness with time after healing and showed no goblet cell appearance on the cornea. This suggests that regenerated epithelium...

Abstract Background Cataract surgery is traumatic to the corneal epithelium,scarring and opacity commonest cause of blindness. Objective To study epithelial thickness in different conditions using anterior segment optical coherence tomography (AS-OCT). Patients Methods A case-control including 80 eyes divided equally into 4 groups; group 1:controls,group 2:corneal scarring ,group 3:cataract pat...

PURPOSE The corneal epithelium is essential for maintaining corneal transparency, and efforts have been made to develop improved techniques for corneal epithelial transplantation in patients with total limbal failure. We evaluated the suitability of transplanted cultivated human conjunctival epithelium (HCjE) as a corneal epithelium replacement in rabbits with total corneal and limbal deficienc...

PURPOSE To investigate the morphology, distribution, and density of inflammatory cells in the corneal epithelium of aqueous tear-deficient dry eye. METHODS Thirty-two patients with non-Sjögren's syndrome (NSS) dry eye, 14 patients with Sjögren's syndrome (SS) dry eye, and 33 healthy volunteers were studied. In vivo laser scanning confocal microscopy was used to investigate both Langerhans cel...

AIMS To determine the effect of intact corneal epithelium on stromal haze and myofibroblast cell formation after excimer laser surgery. METHODS Denuded epithelium alone, photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK), or LASIK with denuded epithelium was performed in rabbit eyes. Postoperative anterior stromal haze was assessed employing a standard scale. Immunohistoc...

The rates of corneal penetration and efflux of phenylephrine (PE) and its metabolites were found to be limited by the epithelium. The rate constant for corneal penetration as measured in a lucite block perfusion system was 1.06 X 10~ hr" when the epithelium was present and 1.25 X 1O~ hr" when the epithelium was denuded. Epithelial removal reduced the half-time (t)/2) for corneal efflux of PE fr...

The purpose of this study is to characterize and compare the ultrastructural changes occurring during the in vivo cultivation of corneal epithelium on amniotic membrane (AM) at several different time points. Corneal burn patients (n=7) with a corneal epithelial defect and severe limbal damage were selected. Initially, AM transplantation with limbal autograft was performed at the acute stage of ...

PURPOSE To investigate corneal abnormalities in heterozygous Pax6(+/Sey-Neu) (Pax6(+/-), small eye) mice and compare them with aniridia-related keratopathy in PAX6(+/-) patients. METHODS Fetal and postnatal corneal histopathology, adult corneal thickness, and the distribution of K12-immunostained cells were compared in wild-type and Pax6(+/-) mice. RESULTS Prenatally, the corneal epithelium...