The concept that cortisolr may be formed by more than one pathway, and pertinent literature leading to this concept, have been discussed previously in reference to the extensive conversion of 17-hydroxypregnenolone to cortisol by slices of a human adrenal cortical tumor (2). Villee et al. (3) demonstrated the conversion of progesterone to 16ac-hydroxyprogesterone (Reaction g, Fig. 1) by homogen...