The production and peripheral metabolism of cortisol have been studied in 10 cirrhotics and 11 controls after i.v. tracers of cortisol-(14)C. The findings were as follows: (a) Total urinary excretion of radioactivity was normal (81% of the dose) but a decreased fraction was present as glucosiduronates: 18-47% of the dose (average 34%) compared to a normal average of 54%. (b) There was a distinc...

Glucocorticoid (GC) action depends on GC plasma concentration, cellular GC receptor expression, and the pre-receptor hormone metabolism catalyzed by 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-Hydroxysteroid dehydrogenase exists in 2 isoforms; 11β-HSD1 converts inactive cortisone to cortisol, and 11β-HSD2 converts cortisol to cortisone. Increasing evidence in humans and experimental animals...

Introduction and Aim: Cortisol has a vital role in helping the body deal with stress. It is known as primary stress hormone. modulates many changes response to stress, including blood glucose metabolism, fat, protein, carbohydrate metabolism into energy (gluconeogenesis), immune anti-inflammatory response. The aim of this study was determine impact Zumba exercise on cortisol levels club partici...

Introduction Cortisol is the main glucocorticoid hormone in humans, important in regulation of salt and water balance, stress response and basal metabolism. The adrenal secrets around 5-15 mg cortisol per day. Only a small fraction is excreted as free cortisol in urine, saliva or bile. The rest is cleared by different metabolic pathways before conjugation-and urinary excretion [1]. In the past ...

OBJECTIVE While systemic glucocorticoids compromise bone metabolism, altered intracellular cortisol availability may also contribute to the pathogenesis of primary male osteoporosis (MO). The objective of this study was to assess whether intracellular cortisol availability is increased in MO due to a distorted local cortisol metabolism. METHODS Forty-one patients with MO were compared with ag...

Incubation of blood from deoxycorticosterone-treated, adrenalectomized dogs with glucose, (22)NaCl, and cortisol, added in vitro, revealed log dose-related acceleration of sodium influx, of glucose utilization, and of lactate formation by cortisol in concentrations between 150 and 1000 microg/liter. Addition of 2-deoxyglucose, or preincubation of the blood until blood glucose concentration had ...

Recent efforts have provided convincing evidence for the use of fish scale cortisol concentration in assessment long-term stress fishes. However, alone is not sufficient to fully describe this state stress. Dehydroepiandrosterone (DHEA) an androgen with actions that oppose those cortisol. The means by which DHEA negates effects occurs part via changes metabolism cortisone. quantitation cortisol...