A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO(2). The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(l-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-...

Because of availability, as well as economical and environmental considerations, natural gas is projected to be the premium fuel of the 21st century. Natural gas production involves risk of the shut down of onshore and offshore operations because of blockage from hydrates formed from coproduced water and hydrate-forming species in natural gas. Industry practice has been usage of thermodynamic i...

the paper is focused on the formation of calcium phosphate nanoparticles (cp) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, anionic surfactantant and cosurfactant, in the presence of anionic and cationic polyelectrolyte. it is shown that polyelectrolyte, can be incorporated into the individual inverse microemulsion droplets. the ...

Aerosol OT（以下，AOTという）と助界面活性剤と鉱物油の混合系における水の可溶化を検討した。可溶化水の状態を簡便かつ有効に評価する方法として濁度法が有用であった。鉱物油には炭素数10～12の長鎖炭化水素が適していた。長鎖炭化水素は逆ミセルの単分子層に浸透し難いために，単分子層の実効体積が増加せず，ミセルサイズは維持されると考えられる。また，助界面活性剤にはソルビタントリオレエート（以下，Span 85という）とソルビタンモノラウレート（以下，Span 20という）が適しており，両者では可溶化水量を増やす機構が異なると考えられた。Span 85はAOT分子の親油基に作用して逆ミセルの単分子層を厚くして鉱物油の浸透を抑えることによって，他方，Span 20はAOT分子と混合ミセルを形成してAOT分子の親水基間の静電的相互作用を弱めることによって，逆ミセルを大きく，かつ，安定化し...

Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules specially BCS Class-II and Class-IV. In order to appreciate the potential ...

BACKGROUND The increased incidence of inflammatory diseases has necessitated the need to search for new topical dosage form of dexamethasone. OBJECTIVES The purpose of the present study was the preparation and evaluation of novel microemulsion as a topical delivery system for dexamethasone by mixing appropriate amount of surfactant including Tween 80 and Labrasol, cosurfactant such as capryol...

sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. the effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. in this investigation, two commercially available lecithins (namely epikuron 2...