نتایج جستجو برای: covalently attachment

تعداد نتایج: 55663  

2016
Christoph H. Emmerich Siddharth Bakshi Ian R. Kelsall Juanma Ortiz-Guerrero Natalia Shpiro Philip Cohen

We have reported previously that activation of the MyD88-signaling network rapidly induces the formation of hybrid ubiquitin chains containing both Lys63-linked and Met1-linked ubiquitin (Ub) oligomers, some of which are attached covalently to Interleukin Receptor Associated kinase 1. Here we show that Lys63/Met1-Ub hybrids are also formed rapidly when the TNFR1/TRADD, TLR3/TRIF- and NOD1/RIP2-...

2004
Darren J. Magda Zhong Wang Nikolay Gerasimchuk Wenhao Wei Pavel Anzenbacher Jonathan L. Sessler

This paper summarizes recent synthetic efforts devoted to the generation of new, second-generation texaphyrin-type drugs, specifically species that involve known or potential anticancer agents covalently attached to a tumor-localizing texaphyrin core. Particular emphasis will be placed on the strategies needed to prepare such systems, as well as on the choice of active group being subject to at...

Journal: :Chemical communications 2015
Junhyeok Seo Ryan T Pekarek Michael J Rose

We demonstrate the covalent attachment and catalytic function of a nickel-phosphine H2 evolution catalyst to a p-Si(111) photoelectrode. The covalently assembled semiconductor|molecular construct achieves a synergistic improvement (ΔVonset = +200 mV) as compared to a solution of [(PNP)2Ni](2+) in contact with a p-Si(111)-CH3 photoelectrode.

2015
Keith A. Williams Peter T.M. Veenhuizen Beatriz G. de la Torre Ramon Eritja Cees Dekker

We have covalently coupled single-walled carbon nanotubes (SWNTs) to peptide nucleic acid (PNA, a synthetic DNA analogue [1]), and shown that the resulting macromolecular wires hybridize with complementary DNA. This provides a powerful tool to incorporate SWNTs into a recognition-based, massively parallel device assembly strategy, and permits sequence-specific attachment of SWNTs to biological ...

Journal: :Chemical communications 2013
Nisha Varghese Sijie Yang Preeti Sejwal Yan-Yeung Luk

Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginin...

Journal: :Journal of cell science 1979
P Knox P Wells

Proteoglycan was isolated from cartilage and freed from contaminating glycoproteins and hyaluronic acid. The macromolecule consists of a protein core covalently linked to a number of glycosaminoglycan side chains, namely chondroitin sulphate and keratan sulphate. This proteoglycan retards the attachment of a variety of cell types to tissue culture plastic and to collagen. Glycosaminoglycans alo...

2012
Alexey V. Kondyurin Pourandokht Naseri Jennifer M. R. Tilley Neil J. Nosworthy Marcela M. M. Bilek David R. McKenzie

The surface of polyethylene was modified by plasma immersion ion implantation. Structure changes including carbonization and oxidation were observed. High surface energy of the modified polyethylene was attributed to the presence of free radicals on the surface. The surface energy decay with storage time after treatment was explained by a decay of the free radical concentration while the concen...

Journal: :BioTechniques 2001
D R Call D P Chandler F Brockman

Microarrays printed on glass slides are often constructed by covalently linking oligonucleotide probes to a derivatized surface. These procedures typically require relatively expensive amine- or thiol-modified oligonucleotide probes that add considerable expense to larger arrays. We describe a system by which unmodified oligonucleotide probes are bound to either nonderivatized or epoxy-silane-d...

Journal: :The Journal of biological chemistry 1992
S P Massia J A Hubbell

Diamines covalently coupled to glass substrates promoted human foreskin fibroblast adhesion in the absence of serum. These diamine-derivatized substrates were produced by coupling ethylene diamine, N-methylaminoethylamine, and N,N-dimethylaminoethylamine (NNDMAEA), to sulfonyl chloride-activated glass. Electron spectroscopy for chemical analysis demonstrated that the diamines were coupled via t...

2002
E. P. Ivanova D. K. Pham Dan V. Nicolau Abraham P. Lee

The immobilization efficiency of the complexes of oligonucleotide/poly(L-lysine) onto Poly(Styrene/Maleic Acid), PSMA, and Poly(Styrene/Maleic Anhydride), PSMAA, has been investigated using X-ray photoelectron spectroscopy and atomic force microscopy (AFM) in conjugation with fluorescence-based measurements of DNA attachment. A mono-molecularly thin layer of either electrostatically or covalent...

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