PURPOSE: Non-syndromic sagittal and/or metopic craniosynostosis, occurring once in every 4,000 live births, accounts for half of all craniosynostosis cases. Despite success in identifying the genes underlying rare syndromic craniosynostoses, mutations in these genes are very rarely found in their non-syndromic counterparts. We considered that the often sporadic occurrence of non-syndromic crani...

plagiocephaly (oblique skull) is premature fusion of one of the coronal sutures. frontal plagiocephaly is a rare congenital deformity in the skull that is the most complicated form of craniosynostosis to treat. examination of all sutures is necessary for diagnosis of craniosynostosis in this article, a 10-month-old, healthy girl with deformity of the right forehead and orbit that is caused by f...

The term “evidence-based medicine,” first used in the 1980s in Canada, is defined as “the conscious, explicit, and critical use of the best available evidence to make medical decisions regarding the care of individual patients.” This study sought to estimate the viability of evi ­ dence­based medicine in modern craniofacial surgery practice 44 years after Paul Tessier first started it by showca...

Introduction: Craniosynostosis are cranial deformities resulting from the early closure of one or more sutures. Concomitant facial changes usually result involvement multiple sutures, which may lead to restriction growth and brain expansion, ocular compression, breathing difficulties. The distraction osteogenesis (DO)for frontofacial posterior advancement have increased safety procedure. aim th...

objective pfeiffer syndrome is as rare as apert syndrome in the western population. this condition is very rare in the asian population. at the best of our knowledge this is the first genetically proven case report from iran. the authors report with a review of literature, the case of a infant with pfeiffer syndrome, manifested by lacunar skull, ventriculomegaly, bicoronal craniosynostosis,fron...