Galanthamine, an isoquinoline alkaloid and the current drug of choice for treatment of mild to moderate Alzheimer disease, is mainly obtained from Amaryllidaceae members. At present, the production of galanthamine from available natural plant sources is not sufficient to meet the demands of pharmaceutical industry. Additionally, overexploitation of the plant material leads to the depletion of a...

Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeyla...

Several major bone diseases are directly attributable to bone loss, including osteoporosis, bone metastasis, and rheumatoid arthritis. The nuclear factor of activated T cell 1 (NFATc1), a transcription factor, has recently been shown to play an essential role in osteoclastogenesis. In this study, we found that of several herbs, Cinnamomum zeylanicum (C. zeylanicum) exhibited the strong inhibito...

The anti-Candida activity of essential oil from Cinnamomum zeylanicum Blume, as well as its effect on the roughness and hardness of the acrylic resin used in dental prostheses, was assessed. The safety and tolerability of the test product were assessed through a phase I clinical trial involving users of removable dentures. Minimum inhibitory concentration (MIC) and minimum fungicidal concentrat...

Cinnamon bark is used as a spice. It is employed in cookery as a condiment and flavouring material. The essential oil of this herb is a potent antibacterial, anti-fungal, and uterine stimulant. It is useful in diarrhoea and haemorrhage of the womb. It also reduces blood sugar and cholesterol level. One of its uses is in musculoskeletal disorder. The aim of the study was to evaluate the centrall...

ETHNOPHARMACOLOGICAL RELEVANCE Hippadine is an alkaloid isolated from Crinum macowanii. Crinum macowanii is used in South Africa to treat oedema, 'heart disease', rheumatic fever, cancer and skin diseases, and belongs to the plant family Amaryllidaceae, assumed to have originated in the South African region. The aim of this study was to evaluate the effect of hippadine, an alkaloid extracted fr...

Tuberculosis (TB) is of great public health burden globally especially in developing countries of Africa and Asia . Current TB regimen involves multiple therapies and of long duration leading to poor patient adherence. There is also the challenge of multidrug resistant TB. Hence, there is a need for discovery of new anti- TB drugs. This study was designed to investigate the in -vitro activity o...