Saffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. These therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. The effect of C. sativus and its constituents on different smooth muscles an...

Memory-related disorders are a common public health issue. Memory impairment is frequent in degenerative diseases (such as Alzheimer's disease and Parkinson disease), cerebral injuries, and schizophrenia. The dried stigma of the plant Crocus sativus L. (C. sativus), commonly known as saffron, is used in folk medicine for various purposes. Several lines of evidence suggest that C. sativus and it...

Stigma of Crocus sativus L. (Iridaceae), commonly known as saffron, is the world’s most expensive spice and apart from its traditional value as food additive recent studies indicate its potential as antidepressant. Because saffron is expensive, using it daily to address depression may not be practical. Moreover, recent study indicated antidepressant effect of petal of Crocus sativus. As petal o...

flavonoids, are a large class of polyphenols, with more than 4000 combinations. they have an antioxidant role in plant photosynthesis and in the human body they optimally act as an antioxidant, anti-inflammatory, anticancer and protector of the heart. quercetin is in the flavonol group that is used to fight protection specifically against viruses and cancer cells. in this study, comparison of e...

background & aim: saffron (crocus sativus l.) formerly was important in turkey. saffron cultivation has been decreased and it is now only cultivated in three villages in this country. it is triploid and exclusively propagated in a vegetative way by corms. in turkey, saffron is traditionally planted by placing corms in rows randomly without grading or sorting; which results in placement of c...

background: tuberculosis continues to be a common health problem worldwide. rifampin, an antibiotic used routinely for tuberculosis chemotherapy is documented to be a potent hepatotoxicant. the aim of the present study was to assess the antioxidant activity of ethanolic extract of crocus sativus l . stigma (eecsl.s) against rifampin induced hepatotoxicity in the rats. materials and methods: mal...

Crocus sativus is a triploid sterile plant characterized by its long red stigmas, which produce and store significant quantities of the apocarotenoids crocetin and crocin, formed from the oxidative cleavage of zeaxanthin. Here, we investigate the accumulation and the molecular mechanisms that regulate the synthesis of these apocarotenoids during stigma development in C. sativus. We cloned the c...