In the undertaken study cross linked egg albumin microspheres of progesterone (PG) have been investigated through the nasal route. A smooth, spherical, cross-linked egg albumin microsphere in the size range of 15-37 μm loaded with progesterone were prepared by multiple emulsion (o/w/o) method by glutarldehyde cross-linking and thermal denaturation techniques. Microspheres were prepared by using...

The objective of the present study was to entrap isoniazid, an Antitubercular drug, in cross linked chitosan matrix and study in vitro lung deposition of powdered chitosan microspheres using Andersen cascade impactor. Ionic cross linker Tripolyphospate was used to make cross linked chitosan microspheres to achieve sustained drug release. Chitosan microspheres were prepared by spray drying metho...

Hydrophilic microspheres based on albumin-heparin conjugates have been prepared as a macromolecular delivery system. The soluble albumin-heparin conjugate was synthesized and crosslinked in a water-in-oil emulsion with glutaraldehyde to form microspheres in the same manner as for albumin microsphere preparation. The microspheres were characterized in terms of their size and swelling properties....

Abstract Electrospun polyvinyl alcohol–dextran (PVA–Dex)-based nanofibers (NFs) are explored as a novel class of bioactive injury dressing materials, which have an essential role for topical mending. Sodium ampicillin-loaded citric acid-cross-linked PVA–Dex NFs were fabricated by electrospinner wound recuperating purposes. Results revealed that PVA (10%)–dextran (10%) cross-linked with 5% acid ...

We measured the size changes of cross-linked polymer microspheres of narrow size distribution with different cross-linking densities by the in situ swelling method. The swelling behavior of these cross-linked polymer microspheres revealed that their maximal swelling degree linearly decreased as a function of the cross-linker content from 6.65 at 1.36 mol% to 2.43 at 3.25 mol%. By means of UV-vi...

The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using formaldehyde and heat treatment. Morphological and ...

−Alginate microspheres incorporating poly(hydroxyethyl acrylate-co-coumaryl acrylate-co-2-ethylhexyl acrylate) (P(HEA-CA-EHA)) were prepared using the water droplets of W/O emulsion as a template. P(HEA-CAEHA) was prepared by a free radical reaction and the HEA/CA/EHA molar ratio was calculated to be 96.1 : 2.0 : 1.9 on the 1H NMR spectrum. The copolymer exhibited a lower critical solution temp...

To prepare the sustained release vitamin C carriers, vitamin C was successfully encapsulated in tripolyphosphate (TPP) cross-linked chitosan (TPP-chitosan) microspheres by the spray-drying method at different manufacturing conditions. Manufacturing parameters (inlet temperature, liquid flow rate, chitosan concentration and volume of 1% w/v TPP solution) had a significant influence on the charac...

Microscopic hydrogel spheres can be used to improve the mechanical properties of conventional hydrogels. We prepared ionic-covalent entanglement (ICE) hydrogel microspheres of calcium cross-linked gellan gum and genipin cross-linked gelatin using a water-in-oil emulsion-based processing technique. The method was optimized to produce microspheres with number average diameter 4 ± 1 μm. These ICE ...

introduction: proteins play a fundamental role in biological systems and are often sensitive against organic solvents, heat and other damaging factors. proteins are the basic component of food formulations and enhancement the functional characteristics and stability of the proteins has always been the main goal of food industry engineers. one of the natural ways used for protein modifications i...