The case-crossover design was developed to study the effects of transient, short-term exposures on the risk of acute events, such as myocardial infarction, in the early 1990s. This paper illustrates how the principles of case-crossover design are related to the principles of crossover and case-control designs and stipulates the possibilities of case-crossover design in air pollution epidemiolog...

Background Autistic spectrum disorder (ASD) refers to a syndrome associated with persistent impairments in communication skills, social interactions, and so forth. Given the approval of risperidone and naltrexone by U.S. Food and Drug Administration (FDA) for ASD cases and extant controversy concerning their pertained side effects, this double-blind, placebo-controlled, crossover clinical trial...

Geometric crossover is a representation-independent generalisation of the traditional crossover defined using the distance of the solution space. By choosing a distance firmly rooted in the syntax of the solution representation as basis for geometric crossover, one can design new crossovers for any representation. In previous work, we have applied geometric crossover to simple permutations. In ...

Geometric crossover is a representation-independent generalization of the traditional crossover defined using the distance of the solution space. By choosing a distance firmly rooted in the syntax of the solution representation as basis for geometric crossover, one can design new crossovers for any representation. In previous work we have applied geometric crossover to simple permutations. In t...

The role of crossover and mutation in Genetic Programming (GP) has been the subject of much debate since the emergence of the field. In this paper, we contribute new empirical evidence to this argument using a rigorous and principled experimental method applied to six problems common in the GP literature. The approach tunes the algorithm parameters to enable a fair and objective comparison of t...