Adjuvant nivolumab demonstrated statistically significant and clinically meaningful improvement in disease-free survival (DFS) vs placebo an acceptable safety profile patients with resected esophageal or gastroesophageal junction cancer (EC/GEJC) who received neoadjuvant chemoradiotherapy (CRT) CheckMate 577. We present new exploratory biomarker analyses from this study. Whole exome sequencing ...

Creatine and phosphocreatine provide an intracellular, high-energy phosphate buffering system, essential to maintain ATP levels in tissues with high energy demands. A specific plasma membrane creatine transporter (CRT) is required for the cellular uptake of creatine. This transporter is related to the gamma-aminobutyric acid (GAT) and norepinephrine (NET) transporters and is part of a large gen...

Tumor regression grading (TRG) reportedly has prognostic value in rectal cancer patients after pre-operative chemoradiotherapy (CRT). The aim of this retrospective study was to differentiate gene expression profiles based on TRG in residual cancer cells after CRT. We evaluated pathological response using the criteria of four TRG systems: the Japan...

BACKGROUND Cardiac electromechanical dyssynchrony causes regional disparities in workload, oxygen consumption, and myocardial perfusion within the left ventricle. We hypothesized that such dyssynchrony also induces region-specific alterations in the myocardial transcriptome that are corrected by cardiac resynchronization therapy (CRT). METHODS AND RESULTS Adult dogs underwent left bundle bran...

Radopholus similis is a migratory plant-parasitic nematode that causes severe damage to many agricultural and horticultural crops. Calreticulin (CRT) is a Ca2+-binding multifunctional protein that plays key roles in the parasitism, immune evasion, reproduction and pathogenesis of many animal parasites and plant nematodes. Therefore, CRT is a promising target for controlling R. similis. In this ...

PURPOSE We previously revealed that the calreticulin (CRT) gene is a candidate oncogene promoting cell migration and invasion and that neuropilin-1 (NRP1) is a possible effector downstream of CRT in esophageal squamous carcinoma cells. This study aims to explore the mechanisms underlying the migration and invasion of esophageal cancer cells regulated by CRT through NRP1. EXPERIMENTAL DESIGN Q...

Expression of the wheat dehydrin gene Cor410b is induced several fold above its non-stressed levels upon exposure to stresses such as cold, drought and wounding. Deletion analysis of the TdCor410b promoter revealed a single functional C-repeat (CRT) element. Seven transcription factors (TFs) were shown to bind to this CRT element using yeast one-hybrid screens of wheat and barley cDNA libraries...

Preoperative chemoradiotherapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer. However, no specific biomarker has been identified to predict a response to preoperative CRT. The aim of the present study was to assess the gene expression patterns of patients with advanced rectal cancer to predict their responses to preoperative CRT. Fifty-nine rectal canc...

The current work investigates whether creatine metabolism is involved in renal adaptation to dehydration. Wistar rats were either deprived of water or induced to drink water abundantly during 60 h. Cortical and medullar mRNA levels of Na(+)/Cl(-)/creatine transporter (CRT), l-arginine: glycine amidinotransferase (AGAT), guanidinoacetate methyltransferase (GAMT) and of the tonicity sensitive gen...

Abstract Purpose: Adding losartan to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection our phase II trial patients with locally advanced pancreatic cancer. Here we identify potential mechanisms of benefit assessing the effects neoadjuvant losartan+FFX+CRT versus FFX+CRT on stromal tumor microenvironment. Experimental Design: We performed a gene...