glucoronoxylomannan (gxm) is the most important compound of polysaccharide capsule in cryptococcus neoformans that causes infection in its recognition as a foreign agent by immune system. because of its similarity with some naural compounds such as heparin and hyaloronic acid, this study was undertaken to determine the effect of polysaccharide compounds on blood coagulative process and renal pe...

BACKGROUND/AIMS Cryptococcus neoformans infections are becoming increasingly prevalent and remain a life-threatening clinical issue in immune-compromised hosts. The microorganism evades a variety of endogenous anti-fungal mechanims of host immune cells. The signaling pathways in human immune cells that become activated in response to Cryptococcus neoformans infection have yet to be fully charac...

The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal pathogens with different phenotypic and genotypic diversity that cause disease in immunocompromised patients as well as in healthy individuals. The immune response resulting from the interaction between Cryptococcus and the host immune system is a key determinant of the disease outcome. The species C. neoforman...

Cryptococcosis is known as a central nervous system infection which is caused by Cryptococcus neoformans (C. neoformans). The contamination is made by inhaling the fungi, then it produces the first lesion in the lung tissue. This phase is non symptomatic. In debilitated people, the infection disseminates and affects the meninges. The AIDS patients are the most affected group, and the disseminat...

One hundred clinical isolates of Cryptococcus neoformans from human immunodeficiency virus (HIV)-infected and non-HIV-infected patients from Brazil, Chile, and Venezuela were separated according to varieties and tested for antifungal susceptibility. A high susceptibility to antifungal agents was observed among all the isolates. The electrophoretic karyotyping of 51 strains revealed good discrim...

Thirty-seven isolates from 10 HIV-negative and 26 HIV-positive patients in Mato Grosso were evaluated. Direct examination, culturing and chemotyping of species were performed. Ketoconazole, itraconazole, voriconazole, fluconazole and amphotericin B were evaluated. Thirty-seven yeasts of Cryptococcus spp were identified, of which 26 were from HIV-positive patients (25 Cryptococcus neoformans and...

A sensitive and diagnostically applicable conjugate for the rapid and accurate detection and identification of Cryptococcus neoformans has been developed. C. neoformans rabbit antisera were produced by 14 daily intravenous injections of 36 million cells for a total dosage of approximately 500 million cells. Cross-staining reactions with species of Cryptococcus other than C. neoformans, as well ...

conclusions chronic meningitis in immunocompromised hosts can be due to more than one pathologic etiology and we should do all diagnostic evaluation to rule out all possible differential diagnosis. introduction cryptococcal meningitis is a rare disorder that is caused by cryptococcus neoformans in immunocompromised host. case presentation the case was a 64-year-old man with a history of stem ce...