OBJECTIVE Clinical trials are lacking in pediatric cerebral sinovenous thrombosis (CSVT). Neonates and children increasingly receive anticoagulant therapy (ACT) based on adult studies. Safety data for ACT in pediatric CSVT are scant and urgently needed. The objective was to assess the safety and outcome of ACT in pediatric CSVT. METHODS In a single-center prospective study, neonates and child...

cerebral sinovenous thrombosis (csvt) is increasingly diagnosed in neonates. despite many studies which have addressed diagnosis and management of pediatric csvt, diagnosis of cvsd in neonates is difficult. a female neonate born by natural vaginal delivery was diagnosed with csvt after initiation of seizure. the seizure was stabilized and after performing diagnostic tests, the diagnosis of csvt...

BACKGROUND/OBJECTIVES Promoter polymorphisms in the plasma glutathione peroxidase gene (GPX3), which encodes a major antioxidant enzyme implicated in post-translational modification of fibrinogen, have been implicated as risk factors for arterial ischemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT) in young adults. However, the contribution of these polymorphisms could not be confirm...

UNLABELLED AIMo describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) in Switzerland. METHOD data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow-up examination and a cognitive assessment were performed (mean fol...

Cerebral venous sinus (sinovenous) thrombosis (CSVT) is a rare life-threatening disorder in childhood that is often misdiagnosed. CSVT encompasses cavernous sinus thrombosis, lateral sinus thrombosis, and superior sagittal sinus thrombosis (SSST). We present an adolescent girl who was well until two weeks earlier when she had a throbbing frontal headache and fever with chills; she later had dys...

Zusammenfassung Die zerebrale Sinusvenen- und Kortikalvenenthrombose (CSVT) ist eine seltene, aber lebensbedrohliche Erkrankung, ihre Diagnose bleibt Herausforderung. Sie manifestiert sich mit einem breiten Spektrum von Symptomen wie Kopfschmerzen, Sehstörungen, fokal neurologischen Ausfällen oder epileptischen Anfällen. Dynamik, Prognose das Ausmaß der Erkrankung hängen maßgeblich Beteiligung ...

Cerebral sinovenous thrombosis (CSVT) is a rare, but potentially serious condition among children which requires a multidisciplinary team approach. Clinical manifestations of CSVT include: headache, vomiting, photophobia, blurred vision, focal or generalized seizures, motor deficits, altered mental status and coma. Objective: Exposure clinical data, laboratory and management in cerebral venous ...

BACKGROUND Thromboembolic events are a known complication of Inflammatory Bowel Disease (IBD) especially during disease relapse, more commonly in deep veins of extremities and lung, and rarely as Cerebral Sinovenous Thrombosis (CSVT). CASE PRESENTATION We describe an 11 year, old male patient with 3 months history of Ulcerative Colitis (UC) who presented as pseudotumor cerebri due to superior...

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Inflammatory bowel diseases are associated with increased risk for thrombotic complications, In patients with ulcerative colitis (UC) cerebral sinus venous thrombosis (CSVT) is an extremely rare complication. We report a patient with active UC and CSVT. The patient was heterozygous for Factor V Leiden and G20210A prothrombin gene mutations without other identifiable precipitating factors. This ...