IL-13 is expressed in lesions of atopic dermatitis (AD) and has been associated with increased disease severity. IL-13 has two cognate receptors: IL-13Rα1 and IL-13Rα2. Although IL-13Rα2 expression is known to be induced in response to IL-13 in keratinocytes, its function in AD has never been evaluated. We characterized the loss of skin barrier function and the development of cutaneous inflamma...

A retrospective study was carried out to evaluate skin diseases associated with Chronic Granulomatous Inflammation at Pakistan Institute of Medical Sciences (PIMS) over a period of six months. There were a total of 249 skin biopsies in this period, among which 14.8 % cases were diagnosed as lesions associated with chronic granulomatous inflammation. Among these cutaneous leishmaniasis constitut...

Animal models of inflammation are used to assess the production inflammatory mediators at sites inflammation, processing pain sensation CNS sites, anti-inflammatory properties agents such as nonsteroidal drugs (NSAIDs), and efficacy putative analgesic compounds in reversing cutaneous hypersensitivity. Detailed this article methods elicit measure carrageenan- complete Freund's adjuvant (CFA)–ind...

Hemophilus pertussis vaccine injected into normal rat skin produced local edema lasting several days. Four to 6 days later the injected site became severely inflamed. When uninjected skin was challenged 5 to 28 days after the initial injection, severe inflammation developed at the site of challenge within 12 to 24 hours. This secondary hypersensitive response was elicited by a dose of vaccine w...

Dysregulated inflammatory responses are known to impair wound healing in diabetes, but the underlying mechanisms are poorly understood. Here we show that the antimicrobial protein REG3A controls TLR3-mediated inflammation after skin injury. This control is mediated by REG3A-induced SHP-1 protein, and acts selectively on TLR3-activated JNK2. In diabetic mouse skin, hyperglycaemia inhibits the ex...

BACKGROUND Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis infla...