It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

background: metastasis is one the most leading cause of death from cancer. the chemokine receptor of cxcr4 has an important role in cell migration and cancer metastasis. additionally, metastasis is always associated with the process of epithelial-mesenchymal transition (emt). in this study the correlation between expression of cxcr4 and emt-tfs has been examined. methods: the expression of cxcr...

Abstract Placental dysfunction originates during placental development, specifically the events of placentation. Vascularization is a key component placentation due to its role in fetal-maternal exchange. Cytokines are regulators development; signaling chemokine ligand 12 (CXCL12) and receptor (CXCR4) drives vascularization. Utilizing an vivo sheep model, we demonstrated that suppressing CXCL12...

Ultraviolet B (UVB) triggers lupus flare by worsening skin lesions and systemic symptoms, i.e. nephritis. We have reported that UVB exposure induces inflammation with neutrophil infiltration extracellular trap (NET) formation in mice. also found induced proteinuria young female lupus-prone The relevant mechanisms regarding dermal-renal crosstalk is unclear. examined lesions, proteinuria, of neu...

The key role of chemokine receptor CXCR4 in the maintenance of stemness property of stem cells has been shown recently. The low level laser irradiation (LLLI) is being used currently in a wide variety of clinical cases as a therapeutic tool for wound healing, relieving pain and destroying tumor cells. The aim of this study was to evaluate the effect of LLLI mimicking low level laser therapy (LL...

Alzheimer's disease (AD) is a degenerative brain with complex clinical manifestations and pathogeneses such as abnormal deposition of beta-amyloid protein inflammation caused by the excessive activation microglia. CXC motif chemokine receptor type 4 (CXCR4) G protein-coupled that binds to ligand 12 (CXCL12) activate downstream signaling pathways, Janus kinase/signal transducer activator transcr...