نتایج جستجو برای: cyclin a2

تعداد نتایج: 48839  

Journal: :Nature 2023

Abstract In mammalian cells, the decision to proliferate is thought be irreversibly made at restriction point of cell cycle 1,2 , when mitogen signalling engages a positive feedback loop between cyclin A2/cyclin-dependent kinase 2 (CDK2) and retinoblastoma protein 3–5 . Contrary this textbook model, here we show that actually fully reversible. Instead, find all cycling cells will exit in absenc...

Aligholi Sobhani, Faride Etesam, Marefat Ghafari, Mohammad Barbarestani, Parichehr Pasbakhsh, Zohreh Alizadeh,

Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this s...

Journal: :Circulation 2006
Y Joseph Woo Corinna M Panlilio Richard K Cheng George P Liao Pavan Atluri Vivian M Hsu Jeffrey E Cohen Hina W Chaudhry

BACKGROUND Heart failure is a global health concern. As a novel therapeutic strategy, the induction of endogenous myocardial regeneration was investigated by initiating cardiomyocyte mitosis by expressing the cell cycle regulator cyclin A2. METHODS AND RESULTS Lewis rats underwent left anterior descending coronary artery ligation followed by peri-infarct intramyocardial delivery of adenoviral...

Journal: :Journal of virology 2012
Jennifer D Oduro Ralf Uecker Christian Hagemeier Lüder Wiebusch

Human cytomegalovirus (HCMV) starts its lytic replication cycle only in the G(0)/G(1) phase of the cell division cycle. S/G(2) cells can be infected but block the onset of immediate-early (IE) gene expression. This block can be overcome by inhibition of cyclin-dependent kinases (CDKs), suggesting that cyclin A2, the only cyclin with an S/G(2)-specific activity profile, may act as a negative reg...

2016
Patrick E. Gygli Joshua C. Chang Hamza N. Gokozan Fay P. Catacutan Theresa A. Schmidt Behiye Kaya Mustafa Goksel Faisal S. Baig Shannon Chen Amelie Griveau Wojciech Michowski Michael Wong Kamalakannan Palanichamy Piotr Sicinski Randy J. Nelson Catherine Czeisler José J. Otero

Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves normal size at birth. To understand the differential requirements of distinct brain regions for Cyclin A2, we utilized neuroanatomical, transgenic mouse, and mathematical m...

Journal: :Cancer research 2014
Lakshmi Gopinathan Shawn Lu Wen Tan V C Padmakumar Vincenzo Coppola Lino Tessarollo Philipp Kaldis

Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In this study, we investigated the role of cyclin A2 in tumorigenesis using a cond...

2017
Qing-Hua Zhang Wai Shan Yuen Deepak Adhikari Jennifer A Flegg Greg FitzHarris Marco Conti Piotr Sicinski Ibtissem Nabti Petros Marangos John Carroll

Cyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in prometaphase within minutes of nuclear envelope breakdown. The role of cyclin A2 in female meiosis and its dynamics during the transition from meiosis I (MI) to meiosis II (MII) remain unclear. We found that cyclin A2 decreases in prometaphase I but recovers after the first meiotic...

Journal: :Molecular medicine reports 2015
Xiang Ma Aichao Zhao Yongzhao Yao Wen Cao Ujit Karmacharya Fen Liu Bangdang Chen Wang Baozhu Huang Ying Yitong Ma

Cyclin‑A2, which is downregulated following birth, has previously been established as a key regulator of the cell cycle. The present study aimed to detect the effects of cyclin‑A2 on myocardial cells by using recombinant adeno‑associated virus 9 (rAAV9). Sixty mice were selected and randomly divided into two groups (n=30). The control group were injected with saline and the experimental group w...

2009
Rolf Aamodt Kristin Jonsdottir Solveig Norheim Andersen Johan Bondi Geir Bukholm Ida R. K. Bukholm

Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992-2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997-2000. There were h...

2017
Rachel S. Lee Suhjin Sohn Ki-Hyuk Shin Mo K. Kang No-Hee Park Reuben H. Kim

Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells. However, soft tissue toxicity, such as oral or gastrointestinal (GI) ulcerations has frequently been reported in N-BP users, suggesting that N-BPs may also directly target...

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