نتایج جستجو برای: cyp2c19 polymorphism

تعداد نتایج: 108891  

Journal: :The Indian journal of medical research 2008
A S Chaudhry R Kochhar K K Kohli

Proton pump inhibitors (PPIs) are extensively metabolized in the liver by CYP2C19, that demonstrates genetic polymorphism with 21 mutant alleles. The subjects can be divided into 2 groups with respect to CYP2C19 phenotypes viz., extensive metabolizers (EMs) and poor metabolizers (PMs) of PPIs. This division results in marked interindividual variations in the pharmacokinetics and pharmacodynamic...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
R J Ferguson S M De Morais S Benhamou C Bouchardy J Blaisdell G Ibeanu G R Wilkinson T C Sarich J M Wright P Dayer J A Goldstein

The 4'-hydroxylation of the S-enantiomer of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This polymorphism shows marked interracial heterogeneity, with the poor metabolizer (PM) phenotype representing 2 to 5% of Caucasian and 13 to 23% of Asian populations. Two defective CYP2C19 alleles, CYP2C19*2 and CYP2C19*3, have been described which account for approximate...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2018
Jiachang Gong Lars Hansen Lisa Iacono

BMS-823778 is a potent and selective inhibitor of 11β-HSD1, an enzyme that regulates tissue-specific intracellular glucocorticoid metabolism and is a compelling target for the treatment of metabolic diseases. Metabolism of BMS-823778 was mediated mainly by polymorphic CYP2C19, with minor contributions from CYP3A4/5 and UGT1A4. The clinical pharmacokinetics (PK) of BMS-823778 was first investiga...

2012
Yun Shi Guo-jun Luo Li Zhang Ji Shi Dao-quan Zhang Jian-min Chen Xiao-bo Chen Zhuo-dong Li Qing Zhao

OBJECTIVES The purpose of this study is to explore the relationship between the interactions of CYP2C19 gene polymorphisms and several environmental factors and oesophageal squamous cell carcinoma (OSCC). METHODS In a case-control study of OSCC patients (n = 350) and healthy controls (n = 350), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reacti...

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

2015
Younes Nozari Sirous Vosooghi Mohammadali Boroumand Hamidreza Poorhosseini Ebrahim Nematipour Mojtaba Salarifar Seyed Ebrahim Kassaian Alireza Amirzadegan Mohammad Alidoosti Ali-Mohammad Haji-Zeinali Sepideh Saroukhani

OBJECTIVE In this case-match study, we evaluated the impact of the CYP2C19*2 polymorphism in the occurrence of in-stent restenosis during a 1-year follow-up period despite adequate dual anti-platelet therapy in Iranian patients having undergone percutaneous coronary intervention (PCI). METHODS This study, conducted at a tertiary referral heart center in Tehran, recruited 100 patients: 50 pati...

Journal: :Xinan Jiaotong Daxue Xuebao 2023

This study aims to investigate CYP2C19 gene polymorphisms and the association between with cardiovascular risk factors major adverse events (MACE) in patients acute myocardial infarction (AMI). A prospective cross-sectional analysis involved 86 AMI enrolled assessed MACE evaluated after three months of treatment. CYP2C19*1*1 genotype accounted for highest prevalence at 54.7%, which means normal...

2015
Amarjit S. Chaudhry Bhagwat Prasad Yoshiyuki Shirasaka Alison Fohner David Finkelstein Yiping Fan Shuoguo Wang Gang Wu Eleni Aklillu Sarah C. Sim Kenneth E. Thummel Erin G. Schuetz

CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the mRNA reading frame, introduces 87 amino acids, and leads to a premature stop codon. The 1000 Genomes project (http://browser.1000genomes. org/index.html) indicated rs12769205 is in linkage disequilibrium with rs4244285 on ...

Journal: :Kardiologia polska 2012
Grzegorz Gajos Jarosław Zalewski Jadwiga Nessler Krzysztof Zmudka Anetta Undas Wiesława Piwowarska

BACKGROUND Antiplatelet properties of omega-3 polyunsaturated fatty acids (PUFA) have been demonstrated in patients with coronary artery disease (CAD). It is unknown whether omega-3 PUFA can enhance platelet inhibition on standard aspirin and clopidogrel treatment in the setting of CYP2C19 loss-of-function polymorphism. AIM To investigate whether omega-3 PUFA are able to modify platelet respo...

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