نتایج جستجو برای: cyp2c19 polymorphisms

تعداد نتایج: 68456  

Journal: :Biology 2021

CYP2C19 polymorphisms are important factors for proton pump inhibitor-based therapy. We examined the genotypes and analyzed distribution among ethnicities clinical outcomes in Indonesia. employed polymerase chain reaction-restriction fragment length polymorphism method to determine evaluated inflammation severity with updated Sydney system. For CYP2C19*2, 46.4% were homozygous wild-type allele,...

2016
Filipp Filippovich Vasilyev Diana Aleksandrovna Danilova Vladimir Sergeevich Kaimonov Yana Valerievna Chertovskih Nadezda Romanovna Maksimova

Allele frequencies of single nucleotide polymorphisms (SNPs) are variable among different populations; therefore the study of SNPs in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. The main goal of the research is to study the polymorphisms of CYP2C9, CYP2C19, VKORC1, and SLCO1B1 in Yakuts. Genomic DNA from 229 Yakut subjects were ...

Alireza Salek Moghaddam, Iraj Milanian, Mahmood Hoormand, Nader Tajik, Negin Zand,

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...

2016
Neha Deshpande Sharanya V. Ravi Kanth V. V. Murthy H. V. V. Sasikala M. Rupa Banerjee Manu Tandan Nageshwar Reddy D.

INTRODUCTION AND OBJECTIVE Polymorphisms in genes encoding drug metabolizing enzymes may lead to varied enzyme activity and inter-individual variability in drug efficacy and/or toxicity. Since CYP2C19 and CYP3A4 genes code for enzymes involved in metabolizing wide variety of drugs including proton pump inhibitors, we sought to identify polymorphisms in these genes in order to study their impact...

2018
Mahshid Dehbozorgi Behnam Kamalidehghan Iman Hosseini Zahra Dehghanfard Mohammad Hossein Sangtarash Maryam Firoozi Fatemeh Ahmadipour Goh Yong Meng Massoud Houshmand

Polymorphisms in the cytochrome P (CYP) 450 family may cause adverse drug responses in individuals. Cytochrome P450 2C19 (CYP2C19) is a member of the CYP family, where the presence of the 681 G>A, 636 G>A and 806 C>T polymorphisms result in the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles, respectively. In the current study, the frequency of the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles in an ...

2017
Eric Rytkin Karin B Mirzaev Elena A Grishina Valeriy V Smirnov Kristina A Ryzhikova Zhannet A Sozaeva Michael Iu Giliarov Denis A Andreev Dmitriy A Sychev

AIM The aim of this study was to determine the impact of CYP2C19 and ABCB1 gene polymorphisms and CYP3A4 isoenzyme activity on stent implantation complications among patients with an acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). PATIENTS AND METHODS Seventy-six patients (median age 63, range 37-91 years) with an ACS who underwent PCI were screened for C...

Journal: :Genetics and molecular research : GMR 2016
Y M Guo Z C Zhao L Zhang H Z Li Z Li H L Sun

The goal of this study was to explore the polymorphisms of CYP2C19 (CYP2C19*2, CYP2C19*3) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) on clopidogrel therapy in Zhengzhou city for guidance on clinical medication and reduction in the incidence of thromboembolic events. Two hundred and thirty-four ACS patients undergoing PCI were included in t...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Anthe S Zandvliet Alwin D R Huitema William Copalu Yasuhide Yamada Tomohide Tamura Jos H Beijnen Jan H M Schellens

PURPOSE The anticancer agent indisulam is metabolized by the cytochrome P450 of enzymes CYP2C9 and CYP2C19. Polymorphisms of these enzymes may affect the elimination rate of indisulam. Consequently, variant genotypes may be clinically relevant predictors for the risk of developing severe hematologic toxicity. The purposes of this study were to evaluate the effect of genetic variants of CYP2C9 a...

Journal: :International journal of clinical and experimental pathology 2015
Yipeng Ding Dongchuan Xu Xiyang Zhang Hua Yang Tingting Geng Ping He Jinjian Yao Shengyang Yi Heping Xu Duoyi Wu Xiang Wang Tianbo Jin

CYP2C19 is a highly polymorphic gene and CYP2C19 enzyme results in broad inter-individual variability in response to certain clinical drugs, while little is known about the genetic variation of CYP2C19 in Li Chinese population. The aim of this study was to identify different CYP2C19 mutant alleles and determine their frequencies, along with genotype frequencies, in the Li Chinese population. We...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2006
Masatomo Miura

Lansoprazole is extensively metabolized by CYP2C19 and CYP3A4 in the liver, whereas rabeprazole is primarily converted non-enzymatically to rabeprazole-thioether, with only some being oxidized by CYP2C19 and CYP3A4. Lansoprazole and rabeprazole possess asymmetric sulfur in their chemical structure and have typically been used clinically as a racemic mixture. This article reviews the pharmacokin...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید