BACKGROUND Plasmodium falciparum causes severe clinical manifestations by sequestering parasitized red blood cells (PRBC) in the microvasculature of major organs such as the brain. This sequestration results from PRBC adherence to vascular endothelial cells via erythrocyte membrane protein 1, a variant parasite surface antigen. OBJECTIVE To determine whether P. falciparum multiple genotype in...

Development of severe disease in Plasmodium falciparum malaria infection is thought to be, at least in part, due to the sequestration of trophozoite-stage infected red blood cells in the microvasculature. The process of cytoadherence is mediated by binding of the parasite protein PfEMP-1 on the surface of infected red blood cells to endothelial cell receptors. Although antimalarial treatments r...

background: cytoadherence of plasmodium falciparum - infected red blood cells to endothelial cells is an important mechanism for parasite survival and a major trigger for diseases pathology. here, we de­scribe a new adhesion assay in which different cell types (cho, cho/cd36 and cho/icam-1) are at­tached to cytodex beads in a mini-column format to measure the relative sizes of various binding s...

BACKGROUND Cytoadherence of Plasmodium falciparum- infected erythrocytes to host cells is an important trait for parasite survival and has a major role in pathology of malaria disease. Infections with P. falciparum usually consist of several subpopulations of parasites with different adhesive properties. This study aimed to compare relative sizes of various binding subpopulations of different P...

Cerebral malaria is thought to involve specific attachment of Plasmodium falciparum-infected knobby red cells to venular endothelium. The nature of surface ligands on host endothelial cells that may mediate cytoadherence is poorly understood. We have investigated the effects of soluble thrombospondin. rabbit antiserum raised against thrombospondin. and human immune serum on cytoadherence of par...

background: cytoadherence of plasmodium falciparum - infected erythrocytes to host cells is an im-portant trait for parasite survival and has a major role in pathology of malaria disease. infections with p. falciparum usually consist of several subpopulations of parasites with different adhesive prop-erties. this study aimed to compare relative sizes of various binding subpopulations of differe...

background: molecules expressed on the surface of infected erythrocytes (ie) with plasmodium falci-parum play important roles in malaria pathogenesis and immune evasion. some of these molecules are specific adhesive ligands mediating adhesion of ie to the vascular endothelium. in the current study, the antigens exposed on the surface of ie with different isolates and various binding subpopulati...

The adherence of Plasmodium falciparum-infected RBC (IRBC) to postcapillary venular endothelium is an important determinant of the pathogenesis of severe malaria complications. Cytoadherence of IRBC to endothelial cells involves specific receptor/ligand interactions. The glycoprotein CD36 expressed on endothelial cells is the major receptor involved in this interaction. Treatment of CD36-expres...

Cerebral malaria (CM), a complication in Plasmodium falciparum infection, causes high mortality among children in malaria endemic areas, with coma as major clinical symptom. Conventional explanation for the pathogenesis of the coma in CM is obstruction of small blood vessels in the brain by parasitized red blood cells which are sequestered there, that cause inadequate blood supply causing hypox...