addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

Objective(s): Amyloid β plaques, in Alzheimer’s disease, are deposits in different areas of the brain such as prefrontal cortex, molecular layer of the cerebellum, and the hippocampal formation. Amyloid β aggregates lead to the release of cytochrome c and finally neuronal cell death in brain tissue. hCG has critical roles in brain development, neuron differentiation, and function. Therefore, we...

conclusions in this experimental study, for the first time in iran the expression and purification of this recombinant protein was done successfully. this recombinant protein could be used as a vaccine candidate and diagnostic purpose in subsequent investigations. results the highest expression of the cytochrome p450 cyp141 protein was obtained by the addition of 1 mm of isopropyl β-d-1-thiogal...

b a ckground: anoph eles fluviatilis , one of the major malaria vectors in iran, is assumed to be a complex of sibling species. the aim of this study was to evaluate cytochrome oxidase i (coi) gene alongside 28s-d3 as a diagnostic tool for identification of an. fluviatilis sibling species in iran. m e t hods: dna sample belonging to 24 an. fluviatilis mosquitoes from different geographical area...

background: the adult female sand flies (diptera: psychodidae) of the subgenus larroussius are important vectors of leishmania infantum (kinetoplastida: tripanosomatidae) in meshkinshahr district, northwest of iran. four phle­boto­mus ( larroussius ) species are present in this area, i.e. phlebotomus ( larroussius ) kandelakii , p. ( la. ) major , p. ( la. ) perfiliewi and p. ( la. ) tobbi . th...

different species of gazelles are among the most endangered mammals on the asian steppes and occur in the central, southern and northwestern regions of iran. the previous conservation efforts in this region have been incomplete due to confusion about the phylogenetic relationship among various populations. so that, different conservation programs such as ex-situ breeding and transfer of captive...

dacarbazine (dtic) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and hodgkin’s disease. dtic is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. the active form prevents the progress of disease via alkylation of dna strand. in the structure of this drug, the imidazole ring, a triazen chain and carboxamide group exist. ...

A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...

This study aimed to improve the quality of cryopreserved goat semen for artificial insemination by the addition of cattle seminal plasma crude protein. Semen collected from cattle and centrifuged to obtain seminal plasma. Then it was purified to obtain the crude protein. The diluent used in this study was milk-yolk. There were three groups, control group without crude protein (P0), the addition...