نتایج جستجو برای: cytogenetics
تعداد نتایج: 10190 فیلتر نتایج به سال:
Learning human cytogenetics is important for biology education and training of clinical cytogenetics technologists. To increase the resources of metaphase spreads with different chromosomes shapes for student practice, we describe effective algorithms for such purposes to enhance our cytogenetics tutorial program.
The presence of certain high-risk cytogenetic abnormalities, such as translocations (4;14) and (14;16) and deletion (17p), are known to have a negative impact on survival in multiple myeloma (MM). The phase 3 study ASPIRE (N = 792) demonstrated that progression-free survival (PFS) was significantly improved with carfilzomib, lenalidomide, and dexamethasone (KRd), compared with lenalidomide and ...
Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma
In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM patients. To address this issue, we investigated the clinicopathological characteristics of HD with high-risk cytogenetics in MM. Ninety-seven patients with MM were included in the study. For m...
OBJECTIVE To compare the sensitivity and specificity of Real Time Polymerase Chain Reaction (RT-PCR) with conventional cytogenetics in diagnosis of chronic myeloid leukemia. STUDY DESIGN A cross-sectional, analytical study. PLACE AND DURATION OF STUDY The Armed Forces Institute of Pathology (AFIP), Rawalpindi, from December 2010 to January 2012. METHODOLOGY A total number of 40 patients w...
BACKGROUND Although cytogenetics-based prognostication systems are well described in acute myeloid leukemia (AML), overall survival (OS) remains highly variable within risk groups. An integrated genetic prognostic (IGP) model using cytogenetics plus mutations in nine genes was recently proposed for patients ≤60 years to improve classification. This model has not been validated in clinical pract...
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