To begin with, let me acknowledge that Drs. Epstein and Schubert are experienced doctors of dental medicine who have been involved in the evaluation and therapy of cytotoxic therapy–related mucositis for a long time. I fully agree with them that cytotoxic therapy–associated mucositis is a major clinical problem and that there is a dearth of good studies that address ways to alleviate the condit...

objective: the number of new cancer cases with considerable mortality is increasing worldwide. since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. gene therapy has widespread systemic cytotoxic effects against tumor cells. rotavirus nsp4 has been shown to elicit extensive cytoto...

CD8⁺cytotoxic T cells, CD4⁺ helper and regulatory cells interact differently with cancer. CD8⁺ cytotoxic recognize the antigens presented by cancer kill in various ways. recruit other immune promote them to destroy cells. On hand, suppress cell proliferation response of both This suppressive mechanism often leads progression These cell-cancer interactions can render conventional treatments inef...

Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of anti-angiogenic therapy and the potential formation of new regions of hypoxia within the tumor after...