the 1,4-dihydropyridine (dhp) derivatives are a known class of calcium channel blockers. some derivatives of dhp showed significant cytotoxicity. it was shown that this effect may not be the result of interaction with ca2+ channels. in this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of dhp containing nitroimidazole moiety on their c4 position on fo...

cladribine, an analogue of deoxyadenosine, is highly toxic for both non-dividing and proliferating cells and has shown activity in the treatment of several malignancies. therefore, the aim of the present study is to investigate the cytotoxicity effect of cladribine (2-cda) on the breast cancer cell line, mcf-7 (estrogen receptor positive, er+). mtt assay, annexin v-fluorescein/pi and hoechst 33...

scorpion venom toxicity is of major concern due to its influence on human activities and public health. we investigated the in-vitro process of cell death caused by two iranian scorpions odontobuthus doriae and bothutus salceyi venom on human cell lines. the aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

Previous studies suggest that metformin may exert a protective effect on cisplatin-induced cytotoxicity in cancer cells, and this finding has led to a caution for considering metformin use in the treatment of cancer patients. However, in this paper we provide the first demonstration that metformin synergistically augments cisplatin cytotoxicity in the esophageal squamous cancer cell line, ECA10...

introduction: endodontic sealers are in direct contact with periradicular tissues and play a critical role in regeneration and pathogenesis of periradicular diseases. the aim of this study was to compare cytotoxicity of four different types of sealers including ah plus, sankin, tubliseal ewt and apexit as well as their effect on cytokine release of l929 fibroblasts. materials and methods: in th...

The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca2+ channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on fo...

The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca2+ channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on fo...

background & objective: chlorhexidine solution is one of the widely used mouth antiseptic liquid that prevents teeth tissue damage and also has application as a root canal antiseptic. in this study, cytotoxicity of 2% chlorhexidine solution is compared with another root canal antiseptic, calcium hydroxide powder. materials and methods: cell cytotoxicity of both chemicals was assessed on culture...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...