BACKGROUND The adipokine leptin regulates energy expenditure, vascular function, bone and cartilage growth as well as the immune system and systemic inflammatory response. Several activating effects towards T cells, monocytes, endothelium cells and cytokine production have been reported suggesting a protective role of leptin in the setting of an acute systemic inflammation. However, the pathoph...

BACKGROUND & AIMS Sustained virological response following interferon-based antiviral treatment of chronic hepatitis C is associated with decreased long-term risk of hepatocellular carcinoma (HCC) in advanced liver fibrosis. An unexpected high rate of HCC recurrence following antiviral treatment using direct-acting antiviral (DAA) has recently been reported. METHODS We analyzed data individua...

BACKGROUND Within the development and approval of several new direct-acting antivirals (DAA) against hepatitis C virus (HCV), a new era of hepatitis C therapy has begun. Even more treatment options are likely to become available during the next 1-2 years. METHODS A summary of the current phase II and III trials investigating DAA and a review of the recent HCV guidelines was conducted. RESUL...

Direct Anonymous Attestation (DAA) is one of the most complex cryptographic protocols deployed in practice. It allows an embedded secure processor known as a Trusted Platform Module (TPM) to attest to the configuration of its host computer without violating the owner’s privacy. DAA has been standardized by the Trusted Computing Group. The security of the DAA standard and all existing schemes is...

Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal models of human disease in which angiotensin II has been implicated, such as cardiac hypertrophy, neointima formation, arteriosclerosis, renal failur...

Double aortic arch (DAA) is a rare vascular congenital abnormality. Since a vascular ring surrounds bronchus and esophagus, any oral or nasal intubation can physically cause fatal aortoesophageal fistula (AEF). We report herein the first case of association of DAA and superior mesenteric artery (SMA) syndrome and the second case of AEF caused by nasogastric intubation in an adult with DAA. A 19...

Direct Anonymous Attestation (DAA) is an anonymous signature scheme designed for anonymous attestation of a Trusted Platform Module (TPM) while preserving the privacy of the device owner. Since TPM has limited bandwidth and computational capability, one interesting feature of DAA is to split the signer role between two entities: a TPM and a host platform where the TPM is attached. Recently, Che...

Direct-acting antivirals (DAAs) against Hepatitis C virus (HCV) show effective antiviral activity with few side effects. However, the selection of DAA-resistance mutants is a growing problem that needs to be resolved. In contrast, miR-122 antagonism shows extensive antiviral effects among all HCV genotypes and a high barrier to drug resistance. In the present study, we evaluated three DAAs (sim...

A possible privacy flaw in the TCG implementation of the Direct Anonymous Attestation (DAA) protocol has recently been discovered by Rudolph. This flaw allows a DAA Issuer to covertly include identifying information within DAA Certificates, enabling a colluding DAA Issuer and one or more verifiers to link and uniquely identify users, compromising user privacy and thereby invalidating the key fe...

Section 2.6 of the article by Lee et al. [2] describes the rationale for the sampling time points, viz: ‘‘Serial venous blood samplings (10 ml) for pharmacokinetic analyses were carried out on all subjects at 0, 0.25, 0.5, 1, 2, 3, 4, 5, 6 and 12 h post study drug administration. We anticipated that the range of sampling time points would cover the duration of early blood pressure response to i...