Infection and increased systemic inflammation cause organ dysfunction death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials are lacking. Whether targeting a serum albumin level 30 g per liter or greater these repeated daily infusions 20% human solution, as compared standard care, ...

BACKGROUND Daily evaluation of multiple organ dysfunction syndrome has been performed in critically ill adults. We evaluated the clinical course of multiple organ dysfunction over time in critically ill children using the Pediatric Logistic Organ Dysfunction (PELOD) score and determined the optimal days for measuring scores. METHODS We prospectively measured daily PELOD scores and calculated ...

Acute mental stress can impair arterial function (e.g., stiffness and endothelial function) transiently. Repeated exposures to stress-induced transient vascular dysfunction in daily life potentially leads persistent dysfunction, which increases the risk of cardiovascular disease. Therefore, it is important devise an effective strategy protect vasculatures from stress, exercise one possible solu...

BACKGROUND Olfactory function can impact food selection. However, few large population-based studies have investigated this effect across different age groups. The objective of this study was to assess the association between subjective olfactory dysfunction (anosmia or hyposmia) and macronutrient intake. METHODS A total of 24,990 participants aged 20 to 98 years were evaluated based on data ...

BACKGROUND Subclinical thyroid dysfunction is common among older people and has been associated with decreased functional capacity but with conflicting data. The aim of this study was to assess the association between subclinical thyroid dysfunction and functional capacity in an elderly population. METHODS We included 5182 participants with a mean age of 75.2 years from the Prospective Study ...

OBJECTIVE To explore whether persons with right- and left-sided cerebrovascular accidents differ significantly in mean impact of neurobehavioural impairments on ability to perform activities of daily living. DESIGN AND SUBJECTS Retrospective study of data from 215 persons (103 right-sided, 112 left-sided cerebrovascular accident). The Activities of daily living-focused Occupation-based Neurob...

background: pre?eclampsia as a hypertensive disorder of pregnancy complicates up to 5–10% of pregnancies worldwide. endothelial dysfunction plays an important role in the pathogenesis of pre?eclampsia. in this study, we aim to evaluate the effect of high?dose folic acid on endothelial dysfunction in pre?eclamptic patients. materials and methods: in this triple?blinded randomized clinical trial,...

PURPOSE Vorinostat is the first US Food and Drug Administration-approved histone deacetylase inhibitor and is indicated for the treatment of refractory cutaneous T-cell lymphoma. We conducted a phase I study to determine the maximum-tolerated dose and pharmacokinetics of vorinostat in patients with hepatic dysfunction. PATIENTS AND METHODS Patients had solid malignancies and acceptable bone m...