I. The Pharmacology of No. 48-80, a Long-Acting Vasodepressor Drug. Peter B. Dews, A. Lloyd Wnuck, R. V. Fanelli, Amos E. Light, John A. Tornaben, Stata Norton, C. H. Ellis and Edwin J. De Beer 1 II. Studies on the Relationship of Metabolic Fate and Hormonal Effects of d,l-Methadone to the Development of Drug Tolerance. Chen-Y#{252} Sung, E. Leong Way and Kenneth G. Scott 12 III. The Action of ...

14 MANAGED CARE / JANUARY 2016 When Turing Pharmaceuticals raised the price of its toxoplasmosis drug, Daraprim, from $13.50 to $750 a pill, it captured the attention of policymakers in Washington that drug pricing was out of control. Now leaders in Congress are holding hearings to probe how drug companies set their prices and proposing legislation that’s aimed at reining in spending on pharmac...

Pyrimethamine (Daraprim) has been ef­ fective in treating acute experimental sys­ temic toxoplasmosis, 1 ' 2 and the work of Ryan 3 and later Perkins 4 suggest that it is of benefit in human ocular disease. Studies by Hogan 5 and Choi 6 on guinea pigs and rabbits raise the possibility, however, that pyri­ methamine may not penetrate into the eye in sufficient quantity to be effective. Further­ ...

Background: Malaria infestation in pregnancy is a major public health concern and ranks amongst the commonest complications of pregnancy in Nigeria. Approximately 50,000 Nigerian women die each year from largely preventable pregnancy related complications. Intermittent preventive therapy for malaria in pregnancy (IPTp) is a key recommendation in the National guideline for malaria treatment in N...

This paper presents a quantitative assessment of adaptation options in the context of forest fires in Europe under projected climate change. A standalone fire model (SFM) based on a state-of-the-art large-scale forest fire modelling algorithm is used to explore fuel removal through prescribed burnings and improved fire suppression as adaptation options. The climate change projections are provid...

Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e. secondary prophylaxis) in patients with human immunodeficiency virus (HIV) or AIDs treated prior to and after the common use (i.e. 1996) of highly active ...

Pyrimethamine (Daraprim (Burroughs Wellcome) ; 2,4diamino-5-p-chlorophenyl-6-ethylpyrimidine) is used in the treatment and prevention of malaria (1). When used in combination with one of the sulfonamides, it is also effective in the treatment of toxoplasmosis (2) and coccidiosis (3). Pyrimethamine is one of a series of 2,4-diaminopyrimidines which have been shown to be antagonists of folic acid...

In the course of a study of the mechanism of action of the antimalarial drug pyrimethamine (Daraprim (Burroughs Wellcome) ; 2,4-diamino-5-p-chlorophenyll6ethyl pyrimidine) (1)) it was observed that cells of Streptococcus jaecalis took up and stored the drug and that glucose greatly inhibited this uptake. When similar experimental conditions were employed for a study of the uptake of folic acid ...

140 I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f M Me ed di ic ca al l S Sc ci ie en nc ce es s Ocular toxoplasmosis is the most frequent cause of posterior uveitis. [1] The parasite has an intracel-lular cycle. During the primary infection, the subject is usually asymptomatic and can present flu-like symptoms. A dissemination of the parasites occurs and the tissular cys...