Functional MRI and PET have demonstrated the existence of resting-state networks in the brain (Gusnard & Raichle, 2001; Raichle et al., 2001; Greicius et al., 2003). Yet the neural correlates and thereby the fine-scale temporal dynamics of the brain's intrinsic network activity remain elusive. A full understanding of the mechanisms at play cannot be achieved without input from electrophysiology...

Importance—The immunopathogenic mechanisms of dry eye disease (DED), one of the most common ophthalmic conditions, is incompletely understood. Data from this prospective, doublemasked, randomized trial demonstrate that targeting interleukin 1 (IL-1) by topical application of an IL-1 antagonist is efficacious in significantly reducing DED-related patient symptoms and corneal epitheliopathy. Obje...

Urban spatial inequality is multidimensional and complex. The extant literature identifies three main theoretically-informed dimensions of inequality—accessibility, environmental conditions, socio-economic conditions. We combine geospatial data on measures across these theoretical to derive a composite index for the city Tehran, Iran. draw respectively from relative geographic locations urban f...

Transcription factors play central roles in numerous diseases yet are notoriously challenging targets for drug development. In this issue of Cell Chemical Biology, Samarasinghe et al., 2021Samarasinghe K.T.G. Jaime-Figueroa S. Burgess M. Nalawansha D.A. Dai K. Hu Z. Bebenek A. Holley S.A. Crews C.M. Targeted degradation transcription by TRAFTACs: factor targeting Chimeras.Cell Chem. Biol. 2021;...

drought forecasting in khash city by using neural network model hossein negaresh associate professor of geography and environmental planningfaculty, university of sistan & baluchestan mohsen armesh holding master degree in climatology in environmental planning extended abstract 1- introduction drought is condition of lack of rainfall and increase in temperature occurring in any climatic condit...

Proteolysis-targeting chimeras (PROTACs) that degrade disease-causing proteins by hijacking the endogenous ubiquitin-proteasome system have emerged as an exciting and transformative technology in both chemical biology drug discovery. Currently, majority of PROTACs use reversible non-covalent ligands for target protein interest (POI) E3 ligase. In this review, we explore burgeoning role irrevers...

•The PAF1 complex and SPT6 have positive roles in transcription elongation•RTF1 stimulate RNA polymerase II elongation distinct ways•Depletion of RTF1 decreases velocity•Loss hinders progression through nucleosomes Transcription by (RNA Pol II) relies on the factors (PAF), RTF1, SPT6. Here, we use rapid factor depletion multi-omics analysis to investigate how these influence activity human cell...