The influence of flower extract of Jasminum grandiflorum was studied for its wound healing activity at a dose of 250 mg/kg body weight, using excision and dead space wound models in rats. The animals were divided into three groups in excision wound model, the controls (n=10) were treated with 0.25% CM cellulose, reference standard (n=10) were treated with sulfathiazole ointment and the experime...

Objective: To investigate the comparative wound-healing potency of aqueous and methanol leaf extracts of Vernonia arborea Hk. Materials and Methods: Excision, incision and dead space wound models were used to evaluate the wound-healing activity of Vernonia arborea Hk., on Swiss Wistar strain rats of either sex. In excision wound model, treatment was continued till the complete healing of the wo...

morinda citrifolia (noni) has been traditionally used for bone and wound healing.   the present study was carried out to investigate the effect of morinda citrifolia leaves on experimental wounds and lipid peroxide levels in rats. effect of aqueous extract of leaves of morinda citrifolia (200 mg/kg) on excision, resutured incision and dead space wound models were studied. measurement of blood m...

Morinda citrifolia (Noni) has been traditionally used for bone and wound healing.   The present study was carried out to investigate the effect of Morinda citrifolia leaves on experimental wounds and lipid peroxide levels in rats. Effect of aqueous extract of leaves of Morinda citrifolia (200 mg/kg) on excision, resutured incision and dead space wound models were studied. Measurement...

BACKGROUND Closed incisional wound surgery frequently leaves dead space under the repaired skin, which results in delayed healing. The purpose of this study was to evaluate the effect of negative pressure wound therapy (NPWT) on incisional wounds with dead space after primary closure by evaluating the fluid volume through the suction drain, blood flow of the skin, tensile strength, and histolog...

OBJECTIVE Crinum jagus (J. Thomps.) Dandy commonly called Harmattan or St. Christopher's lily belonging to the family Liliaceae is widely used traditionally in Southeastern Nigeria for treatment of skin sores. This study investigated the wound healing potentials of methanolic C. jagus bulb extract (MCJBE) using incision, excision, and dead space wound healing models. MATERIALS AND METHODS Phy...

Objective: To investigate the effect of tinospora cordifolia (TC) on resutured incision and dead space wounds in albino rats. Materials and Methods: Resutured incision and dead space wounds were inflicted in albino rats under light ether anesthesia with aseptic precautions. Treatment group received tinospora cordifolia and control animals received vehicle orally for a period of 10 days. On the ...

BACKGROUND Catharanthus roseus L (C. roseus) has been used to treat a wide assortment of diseases including diabetes. The objective of our study was to evaluate the antimicrobial and wound healing activity of the flower extract of Catharanthus in rats. METHODS Wound healing activity was determined in rats, after administration (100 mg kg-1 day-1) of the ethanol extract of C. roseus flower, us...

Wound healing is a complicated, multistep process involving many cell types, growth factors and compounds(1-3). Because of this complexity, wound healing studies are most comprehensive when carried out in vivo. There are many in vivo models available to study acute wound healing, including incisional, excisional, dead space, and burns. Dead space models are artificial, porous implants which are...

With a view to investigate the contribution and role of environment within a wooden pyramid model on the wound healing suppressant effect of dexamethasone in rats, wound breaking strength, dry weight, hydroxyproline content and histology of granulation tissue of the dead space wound were studied in rats. The results indicate that the environment within the wooden pyramid not only promotes signi...