نتایج جستجو برای: delta4

تعداد نتایج: 248  

2009
Xiao Meng Yajing Zhou Sufang Zhang Ernest Y. C. Lee David N. Frick Marietta Y. W. T. Lee

Human DNA polymerase delta (Pol delta4), a key enzyme in chromosomal replication, is a heterotetramer composed of the p125, p50, p68 and p12 subunits. Genotoxic agents such as UV and alkylating chemicals trigger a DNA damage response in which Pol delta4 is converted to a trimer (Pol delta3) by degradation of p12. We show that Pol delta3 has altered enzymatic properties: it is less able to perfo...

Journal: :Fertility and sterility 2005
Mohammed Salleh M Ardawi Abdulrahim A Rouzi

OBJECTIVE To determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (IR). DESIGN Case-control study. SETTING Tertiary-referral university hospital. PATIENT(S) One hundred eighty selected women were classified a...

Journal: :The Biochemical journal 2003
Chun-Fa Zhang Savita Dhanvantari Hong Lou Y Peng Loh

Carboxypeptidase E (CPE) functions as a regulated secretory pathway sorting receptor for several prohormones, including pro-opiomelanocortin (POMC), proenkephalin and proinsulin. The association of CPE with lipid rafts in the trans -Golgi network and secretory granule membranes is necessary for its sorting receptor function. We now provide evidence that a domain within the C-terminal 25 residue...

2015
Dewayne L. Defoor Luis A. Vazquez‐Quino Panayiotis Mavroidis Nikos Papanikolaou Sotirios Stathakis

In this project, we investigated the use of an electronic portal imaging device (EPID), together with the treatment planning system (TPS) and MLC log files, to determine the delivered doses to the patient and evaluate the agreement between the treatment plan and the delivered dose distribution. The QA analysis results are presented for 15 VMAT patients using the EPID measurements, the ScandiDos...

2013
Guangjun Li Sen Bai Nianyong Chen Lansdale Henderson Kui Wu Jianghong Xiao Yingjie Zhang Qingfeng Jiang Xiaoqin Jiang

The purpose of this study is to evaluate the sensitivities of 3D diode arrays to setup error for patient-specific quality assurance (QA) of volumetric-modulated arc therapy (VMAT). Translational setup errors of ± 1, ± 2, and ± 3 mm in the RL, SI, and AP directions and rotational setup errors of ± 1° and ± 2° in the pitch, roll, and yaw directions were set up in two phantom systems, ArcCHECK and...

2017
Dewayne L. Defoor Sotirios Stathakis Joseph E. Roring Neil A. Kirby Panayiotis Mavroidis Mohammad Obeidat Nikos Papanikolaou

A patient specific quality assurance (QA) should detect errors that originate anywhere in the treatment planning process. However, the increasing complexity of treatment plans has increased the need for improvements in the accuracy of the patient specific pretreatment verification process. This has led to the utilization of higher resolution QA methods such as the electronic portal imaging devi...

Journal: :The Biochemical journal 2004
Fumio Omae Masao Miyazaki Ayako Enomoto Minoru Suzuki Yusuke Suzuki Akemi Suzuki

The C-4 hydroxylation of sphinganine and dihydroceramide is a rate-limiting reaction in the biosynthesis of phytosphingolipids. Mouse DES1 (MDES1) cDNA homologous to the Drosophila melanogaster degenerative spermatocyte gene-1 (des-1) cDNA leads to sphingosine Delta4-desaturase activity, and another mouse homologue, MDES2, has bifunctional activity, producing C-4 hydroxysphinganine and Delta4-s...

Journal: :Endocrine journal 2008
Etsuko Hisanaga Kee-Yong Park Satoko Yamada Hiromi Hashimoto Toshiyuki Takeuchi Masatomo Mori Masaharu Seno Kazuo Umezawa Izumi Takei Itaru Kojima

The present study was conducted to establish a method to induce differentiation of bone marrow (MB)-derived mesenchymal cells into insulin-producing cells. When mouse BM-derived mesenchymal cells were cultured for 60 days in medium containing 10% fetal calf serum and 25 mM glucose, they expressed insulin. Addition of activin A and betacellulin (BTC) accelerated differentiation, and immunoreacti...

Journal: :FEBS letters 2008
Cátia C P Aires Graça Soveral Paula B M Luís Herman J ten Brink Isabel Tavares de Almeida Marinus Duran Ronald J A Wanders Margarida F B Silva

The pyruvate uptake rate in inverted submitochondrial vesicles prepared from rat liver was optimized and further characterized; the potential inhibitory effects of the anticonvulsive drug valproic acid or 2-n-propyl-pentanoic acid (VPA), Delta4-valproic acid or 2-n-propyl-4-pentenoic acid and the respective coenzyme A (CoA) conjugates were studied in the presence of a proton gradient. All teste...

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