نتایج جستجو برای: demyelination multiple sclerosis

تعداد نتایج: 789302  

Journal: :Brain : a journal of neurology 2009
E C Tallantyre L Bø O Al-Rawashdeh T Owens C H Polman J Lowe N Evangelou

The pathological substrate of progressive disability in multiple sclerosis is hypothesized to be axonal loss. Differences in the demographic, pathological and radiological features of patients with primary progressive compared with secondary progressive multiple sclerosis raise the question as to whether they actually represent separate clinical entities. So far, large pathological studies comp...

Journal: :Biomedical Journal of Scientific and Technical Research 2022

Multiple sclerosis is a chronic inflammatory disease of the central nervous system which results in formation focal convergent lesions primary demyelination white and gray matter brain to spread damage neurodegeneration [1].

Journal: :Journal of the Neurological Sciences 2015

Journal: :Journal of neurology, neurosurgery, and psychiatry 1999
C A Davie N C Silver G J Barker P S Tofts A J Thompson W I McDonald D H Miller

OBJECTIVE To determine non-invasively the relation between the degree of axonal loss and the extent of demyelination in chronic lesions visible on MRI in patients with different subgroups of clinically definite multiple sclerosis using (1)H magnetic resonance spectroscopy ((1)H MRS) and magnetisation transfer imaging (MT). Conventional MRI is unable to differentiate between the various patholog...

Journal: :Progress in Neurology and Psychiatry 2023

MOG antibody disorder presenting as a combined central and peripheral demyelination (CCPD) is uncommon. CCPD has been associated with other primary syndromes such multiple sclerosis, neuromyelitis optica or chronic inflammatory demyelinating polyneuropathy. Here, the authors describe diagnosis management of 21-year-old female historically sequential plaques in her right thalamus, cervical cord,...

Journal: :iranian journal of child neurology 0
mahmoud reza ashrafi tehran university of medical science alireza tavasoli tehran university of medical science houman alizadeh tehran university of medical science javad zare noghabi ardabil university of medical science nima parvaneh tehran university of medical science

abstract background: a tumefactive lesion of central nervous system (cns) is defined as a mass-like lesion with a size greater than 2 cm in brain (magnetic resonance imaging) mri. neuroimaging may help to distinguish the nature of a tumefactive lesion and therefore can prevent an unnecessary brain biopsy. method: in this paper, we have emphasized on determining the nature of a cns tumefactive l...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Katerina Akassoglou Ryan A Adams Jan Bauer Peter Mercado Vivian Tseveleki Hans Lassmann Lesley Probert Sidney Strickland

In multiple sclerosis, in which brain tissue becomes permeable to blood proteins, extravascular fibrin deposition correlates with sites of inflammatory demyelination and axonal damage. To examine the role of fibrin in neuroinflammatory demyelination, we depleted fibrin in two tumor necrosis factor transgenic mouse models of multiple sclerosis, transgenic lines TgK21 and Tg6074. In a genetic ana...

Journal: :research in molecular medicine 0
narges karimi department of neurology, clinical research development unit of bou ali sina hospital, mazandaran university of medical sciences, sari, iran nasim tabrizi department of neurology, clinical research development unit of bou ali sina hospital, mazandaran university of medical sciences, sari, iran mahmoud abedini department of neurology, clinical research development unit of bou ali sina hospital, mazandaran university of medical sciences, sari, iran

multiple sclerosis (ms) is a chronic inflammatory demyelinating disease of the central nervous system that inflammation, demyelination, oligodendrocyte loss, gliosis, axonal injury and neurodegeneration are the main histopathological hallmarks of the disease. although ms was classically thought as a demyelinating disease, but axonal injury occurs commonly in acute inflammatory lesions. in ms mi...

Journal: :PLoS ONE 2007
Roman H. Khonsari Vincent Calvez

Baló's concentric sclerosis is a rare atypical form of multiple sclerosis characterized by striking concentric demyelination patterns. We propose a robust mathematical model for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis. A reconsideration of the analogies between Baló's sclerosis and the Liesegang periodic precipitation phenomenon led us to propo...

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