TRLs have the benefit of providing a common understanding of the status of a technology in its development pathway, a means of assessing and managing risk, and decision making concerning funding and implementation of technology. As with any management tool, there are certain limitations and disadvantages to its use. These include the creation of extra reporting, paperwork, reviews, lengthy adop...

This new disease was first described last year by Dr. Hart and Professor Dent and their colleagues (Baron, Dent, Harris, Hart and Jepson, 1956) under the title 'Hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant aminoaciduria, and other bizarre biochemical features'. The name 'Hartnup disease'-after the family then described-was later used in a reference to the syndro...

Dent’s disease (MIM #300009) is a rare X-linked disorder characterized by various degrees of proximal tubular (PT) dysfunction, nephrocalcinosis and nephrolithiasis. The exact prevalence is unknown. The disease was first reported by Dent and Friedman, who described two males with vitamin D resistant rickets, hypercalciuria and low molecular weight proteinuria (LMWP) (Dent & Friedman, 1964). Bas...

Dent disease is an X-linked tubulopathy, characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis and nephrolithiasis that may progress to advanced renal failure [1,2]. During the last decade, loss-of-function mutations of the CLCN5 gene, which is located in chromosome Xp11.22 and encodes the renal chloride/proton antiporter ClC-5, have been consistently reported in p...

We argue that individual characteristics of managers can explain capital structure decisions like debt conservatism and pecking-order …nancing choices. Moreover, they can explain cross-sectional variation in these decisions despite identical …rm characteristics. We link the reluctance of (some) managers to access external capital markets, and in particular equity markets, to managerial overcon…...

Maria Doukantzi, Dr Med Dent/Philippe Mojon, Dent/Ana Todorovic, Dent/Najla Chebib, Dent/Bjarni Elvar Pjetursson, Prof Dent, PhD/Sabrina Maniewicz, Dent/Irena Sailer, Dent: Purpose: To investigate the differences in accuracy (ie, trueness and precision) of five different optical impression systems. Materials Methods: The following systems was tested: (1) CEREC Bluecam (BL); (2) Omnicam (OM); (3...

germination is series of biochemical reactions that depends mainly on temperature and moisture. therefore, seed germination rate of lemon balm (mellissa officinalis l.) were evaluated in temperatures of 20, 23, 25,27, 30 and 32ºc and water potentials of 0, -0.2, -0.4, -0.6 and -0.8mpa. according to the results, germination temperature window was not very wide in a way that germination temperatu...

it is very important to find the best model to quantify seed germination rate on the response of temperature which it can be used in determination of cardinal temperatures. this study was conducted to evaluation nonlinear regressions models for description wheat (cv. morvarid) germination rate response to temperatures and water potentials. therefore, seeds germination rate were evaluated in tem...