Running title: Martin et al.; Cumulative lipid exposure and how to stay young Ad Ad ddr dr dres es ess s s fo fo for r r Co Co orr rr rres es e p po pond nd nden e ce ce ce: D Depa t rtme t nt of f M Medi di i cine/C /Cardi di l olog

Several DNA regions containing genes involved in poly-beta-hydroxybutyrate (PHB) biosynthesis and degradation and also in fatty acid degradation were identified from genomic sequence data and have been characterized in the serine cycle facultative methylotroph Methylobacterium extorquens AM1. Genes involved in PHB biosynthesis include those encoding beta-ketothiolase (phaA), NADPH-linked acetoa...

The biosynthetic gene cluster of FK228, an FDA-approved anticancer natural product, was identified and sequenced previously. The genetic organization of this gene cluster has now been delineated through systematic gene deletion and transcriptional analysis. As a result, the gene cluster is redefined to contain 12 genes: depA through depJ, depM, and a newly identified pathway regulatory gene, depR.

⁎ Corresponding author at: Neurosurgical Clinic, Depa Medicine and Clinical Neurosciences, University of Paler 129, 90127, Palermo, Italy. Fax: +39 091 6552393. E-mail address: [email protected] (D.G. Iaco http://dx.doi.org/10.1016/j.inat.2014.04.002 2214-7519/© 2014 The Authors. Published by Elsevier B Article history: Received 17 February 2014 Revised 27 March 2014 Accepted 12 April 2014

'Depa rtment of Computer Science, Technische Univers itaet Darmstadt, Fraunhoferstrasse 5, FG GRI S, Darmstadt, Hessen 64283, Germany. E-mails: [email protected] .tu-darmstadt.de; sebastian.bremm@gris . i nfo rmatik . tu-darmstadt.de bFraunhofer Institute for Computer Graphics Research IGD, Fraunhoferstrasse 5, D-64283 Darmstadt, Germany. E-ma il : tatiana. vonJandesberger@gris . i...

An earlier in vitro screening of N,N-diethyl-3-methylbenzamide (Deet) and N,N-diethylphenylacetamide (DEPA) analogs showed that two DEPA analogs, N,N-diethyl(3-bromophenyl) acetamide and N,N-diethyl[(alpha,alpha,alpha-trifluoro-m-tolyl)]acetamide, and one Deet analog, N,N,diethyl[3-(trifluoromethyl)]benzamide, had biting-deterrent activities that were superior to Deet against Aedes aegypti (L.)...

Depa~nnent of.4i~imaI Sciences, Universiry of Illinoi~ at Urhnna-Champaign, Urhana, Illinois 61801 I; Qrreenslnnd Beef Indzrstq Institute, Qzreensland Deparrmem qf Primary Industlz'rs, :Woorooka, Queensland 4105. ~us t ra l i a~ ; Deparrmenr of Arctic Biolog?, and Institute of Medical Biolo~);, Uni~recsity of Trom~g, N-9037 Tromsg, iVon4~a);'; and National Instihte of'Advanced Industrid Science...

Bin WU ,Shikai YAN ,Ziyin SHEN ,Weidong ZHANG , 3 1 . Institute of Chinese Integrative Medicine , Huashan Hospital ,Fudan U nive rsity , Shanghai 200040 , China 2 .Depa rt ment o f Na tural Medicinal Chemist ry , Scho ol of Pha rmacy , Shanghai Jiao Tong University , Shanghai 200030 ,China 3 .Depar tment of Natural Medicinal Chemist ry ,School of Pharmacy , Second Military Medical University...