conclusions the significant difference between groups 1 and 3 permits to establish a correlation between degree of nicotine addiction and hearing loss. however, further studies are needed to identify the mechanisms leading to hearing loss. patients and methods the study recruited smokers (100) and non-smokers as a reference group (100) aged 21 to 50 years living in noisy or quiet areas of beiru...

a recent study indicates that the incidence of smoking cessation varies with age. although nicotine dependence (nd) has been regarded as one of the most significant barriers of successful smoking cessation, few researches have focused on the relationship between nicotine dependence and age.a cross-sectional study (conducted in 2013) with 596 chinese rural male current smokers was performed to s...

objectives: dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. in the present study, the effects of thymoquinone, the major constituent of nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. materials and methods: male adult nmri mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 7...

aim: the purpose of this study was to compare the attention bias about tempting incentives related to opium materials in treated, addicted and normal people. duration of consumption and treating were also considered. method: in this causal-comparative study population was all addicted people who were referred to the rehabilitation offices, addiction treatment clinic, rebirthing centers and narc...

background: the effects of opium dependence on prognosis and short term outcome of patients with acute myocardial infarction (ami) are not clear yet. methods: from march 2004 to august 2004 all male patients admitted with diagnosis of ami were enrolled. patients who fulfilled dsm- iv-tr criteria were chosen as opium dependent patients (odp). demographic data, risk factors, peak enzyme levels, l...

conclusions low onset age of smoking cigarettes, high novelty seeking and low cooperativeness in opiate dependents are among the important personality traits in future use of drugs that can predict the subsequent onset of using opiate drugs. results opiate addicts had higher scores in novelty seeking dimension and lower scores in cooperativeness compared to nicotine addicts. the onset age of sm...

conclusions results showed that sexual dysfunction is a prevalent disorder in opioid-dependent males. addiction withdrawal centers should be warned about the dysfunction caused by opioids and, from a clinical perspective, it is imperative that patients misusing opiates and those treated with methadone are routinely asked about their sexual functioning so that, if indicated, appropriate investig...

background :impact of substance abuse on outcome of hospitalized patients with acute myocardial infarction (mi) is a frequent question. available studies show disagreements over its impact, thus we performed this study to find a clear answer.   methods : in a cross sectional study, 304 patients (include 152 consecutive opium dependents and equal number of independents) with acute mi admitted to...

glutathione s-transferases (gsts; ec: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. functional genetic polymorphisms in genes encoding gstm1 (a member of gst class mu; omim: 138350), and gstt1 (a member of gst class theta; omim: 600436) have been well defined. the functional null alleles of gstm1 and gstt1 represent deletions of gstm1 and gs...

background and objective: today, opioids are used to control and relieve acute and chronic pain. however, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. so, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined.    materials and methods: ninety-eight mic...