a series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (hqsar) analysis. a training set containing 24 compounds served to establish the hqsar model. the best hqsar model was generated using atoms, bond, connectivity, donor and acceptor as fragment d...

parkinson’s disease is the second most common age associated neuron degenerative disorder in developed societies. with the prevalence ranging from 41 per 100000 in the fourth decade of life to over 1900 per 100000 in people over 80 years of age.it characterized clinically by resting tremor, slowness of movement, rigidity and postural instability in the result of progressive loss of dopaminergic...

objective(s) inhibitors of p38 map kinase are considered as suitable target in the treatment of inflammatory diseases such as rheumatoid arthritis and bowel inflammatory diseases. the development of 5-alkylthio-1-aryl-2-(4-pyridinyl) triazoles as inhibitors of p38 map kinase is described. these are analogues of 4- pyridinyl imidazole p38 map kinase inhibitor reported by merck research laborator...

objectives: following the rise in the elderly population worldwide and the increase in chronic diseases among this demographic with their consequent need for care, the subject of elderly care is becoming increasingly important. considering the traditional standing of the elderly in iranian society and the importance of in-community care for them, it seems of crucial importance to study the obst...

dyslipidemia has become a common problem in human immunodeficiency virus (hiv) disease, especially in patients on combination antiretroviral therapy. we investigated the prevalence of and factors associated with dyslipidemia in hiv-infected patients in iran. in this cross-sectional study, 190 hiv positive patients who referring to behavioral disease consulting centers (shemiranat, varamin) and ...

alkyl imidazolines have been reportedly used in a wide range of industrial formulations with different applications. ethoxylated alkyl imidazolines with appropriate ethoxylation degrees can be used as antioxidants and retarders in the formation of peroxides resulting from oxidation in hydrocarbon media. in this work, ethoxylated imidazolines were shown to be more effective in hydrocarbon media ...

introduction: in patients with uncomplicated primary hypertension (htn), angiotensin converting enzyme inhibitors (aceis) are considered as monotherapy. in some studies, cough was not related to age, sex, underlying disease, or drug dosage. however, in previous studies, the incidence of cough was greater in females than males. the aim of this study is to determine the incidence of captopril-ind...

a group of 1,3-biarylhydrazide derivatives possessing a cox-2 azido pharmacophore at the para- position of the c-1 phenyl ring in conjunction with a n-3 phenyl or substituted-phenyl ring (4-f,4-cl,4-ome) were designed and synthesized based on nucleophilic substitution reaction. a molecular modelling study of these compounds showed that the designed molecules were well bound with the active site...

objective: hypoglycemia with multiple etiologies is a common in diabetic patients. the current study describes the probability of interaction between maprotiline, selective serotonine reuptake inhibitors like citalopram for induction of hypoglycemia. case presentation: a 47 year-old diabetic woman used tablet citalopram 20mg daily because of generalized anxiety disorder from two years ago, but ...