The color of the gingiva has an important role in determining esthetics individual. There are many etiological factors responsible for gingival pigmentation. Depigmentation can be done by various procedures which include scalpel surgery, cryosurgery, bur abrasion, laser surgery and electrosurgery. Among these procedures, depigmentation is most comfortable method.

Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting in part limited knowledge of disease pathogenesis. Existing mouse models of vitiligo consist of hair depigmentation but lack prominent epidermal involvement, which is the hallmark of human disease. They are th...

The pigment molecule, melanin, is produced from melanosomes of melanocytes through melanogenesis, which is a complex process involving a combination of chemical and enzymatically catalyzed reactions. The synthesis of melanin is primarily influenced by tyrosinase (TYR), which has attracted interest as a target molecule for the regulation of pigmentation or depigmentation in skin. Thus, direct in...

In vitiligo, gradual cutaneous depigmentation and cytotoxic T-cell activity against melanocytes are accompanied by a paucity of regulatory T cells (Tregs) in vitiligo patient skin, indicating that autoimmune responses are not adequately held in check. Thus, we sought a means to repopulate patient skin with Tregs. We hypothesized that enhanced expression of CCL22 can promote Treg skin homing to ...

Hair depigmentation is very rare presentation of cystic fibrosis (CF). We present 3.5-month-old female patient who had dermatitis and depigmentation of hair and eye lashes, malnutrition, edema and anemia as presenting symptoms of CF. After pancreatic enzyme and vitamin supplementation therapy, skin changes gradually disappeared, and her hair regained its normal brown colour.

TO THE EDITOR: A 69-year-old Indigenous Australian man, with no known Caucasian ancestry, presented in 2008 with a 7week history of depigmentation of the face and neck, which was initially intensely pruritic and erythematous. He had neither a personal history nor family history of vitiligo, but a 2 mm thick, Clark level III, superficially spreading melanoma had been widely excised from his righ...

Background: Although cryotherapy has been reported as atechnique for depigmenting residual pigmented patches inpatients with universal vitiligo, Q-switched Nd-YAG lasershave not yet been used for this purpose. The aim of this studywas to compare the efficacy of cryotherapy with that of 532nmQ-switched Nd-YAG laser therapy for depigmentation in patientswith universal vitiligo.Method: Six adult p...