Explanation.................................................................................................. 316 Evaluation for acceptable daily intake......................................................... 316 Biochemical aspects ....................................................................... 316 Absorption, distribution and excretion.................................. 316 Biotransfo...

Explanation.................................................................................................. 149 Evaluation for acceptable daily intake......................................................... 150 Biochemical aspects........................................................................... 150 Absorption, distribution and excretion ....................................... 150 B...

A series of 111 thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds were evaluated as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model. All derivatives tested were potent inhibitors of virus replication with mean 50% inhibitory concentrations of 1.1 micrograms/ml for both type 1 and 2 herpes simplex virus. ...

the isocyanates are widely used as precursors of polyurethane products, as well as carbamate insecticides. toluene 2,4-diisocyanate (tdi) is one of the most important commercially used isocyanates. humans may be exposed to tdi by inhalation, ingestion, dermal and eye contact. tdi is a powerful irritant to the mucosal membranes of the gastrointestinal and respiratory tracts, eyes and the skin. p...

Explanation.................................................................................................... 275 Evaluation for acceptable daily intakes ........................................................ 276 Biochemical aspects ................................................................................ 277 Absorption distribution and excretion ........................................

Explanation.................................................................................................... 333 Evaluation for acceptable daily intake .......................................................... 333 Biochemical aspects ................................................................................ 333 Absorption, distribution and excretion ......................................

Acute Toxicity Studies with Insect Attractants. BEROZA, M., INSCOE, M. N., SCHWARTZ, P. H., JR., KEPLINGER, M. L. AND MASTRI, C. W. (1975). Toxicol. Appl. Pharmacol. 31, 421-429. Eight insect attractants and one inhibitor of a sex attractant were tested for acute oral and aerosol inhalation toxicity in rats, for acute dermal toxicity, eye irritation, and primary skin irritation on rabbits, and ...

in recent years, it has become evident that it is necessary to systematically and accurately define particle characteristics in order to understand the potential toxicity of nanoparticles to biological systems. the properties that need to be emphasized are size, shape, dispersion, doping, aggregation, functionalization, physical and chemical properties, surface area, and surface chemistry. rout...

The use of miniature swine as a non-rodent species in safety assessment has continued to expand for over a decade and their use has become routine, particularly in pharmacology as a model for human integumentary diseases. Translational preclinical swine study data are now favorably compared and contrasted to human data, and miniature swine models provide important information in dermal safety a...

Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here...