LTHOUGH clinical studies on the efficacy of desoxycorticosterone therapy A in epilepsy have yielded contradictory results (I, 2), in a few cases a significant decrease in the incidence of grand ma1 seizures has been noted (2). This improvement in the clinical status of the patients was apparently due to a retention of Na in the body, and a loss of K (3). Spiegel (4) administered desoxycorticost...

It was previously reported by the authors (1) that, in a normal rat with daily administration of 100 mg/kg borneol and intraperitoneal injection of 400 mg/kg glucuro nolactone for the period of 13 days, the amounts of total glucuronic acid, of o-glucuronide and of 1-ascorbic acid excreted in rat's urine, increased significantly, and that, in a bilate rally adrenalectomized rat administrated dai...

The electrolyte content of paraffin-stimulated, whole, mixed saliva obtained from patients with congestive heart failure is characterized by lower sodium, lower chloride, and higher potassium concentrations than saliva of normal subjects (1). Since these data suggested possible increased adrenal cortical activity in patients with heart failure, desoxycorticosterone acetate (DCA) was administere...

• The concept of an endocrine relationship between adrenals and kidneys has recently received considerable support. Adrenalectomy causes an increase in granularity of the juxtaglomerular cells and in pressor substances contained in kidneys; desoxycorticosterone has the opposite effects while cortisone and cortisol are reported, without supporting data, to have no effects.' It is not clear what ...

The electrolyte content of paraffin-stimulated, whole, mixed saliva obtained from patients with congestive heart failure is characterized by lower sodium, lower chloride, and higher potassium concentrations than saliva of normal subjects (1). Since these data suggested possible increased adrenal cortical activity in patients with heart failure, desoxycorticosterone acetate (DCA) was administere...

Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen biosynthesis were shown to be increased, including prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase), prolyl hydroxylase-related a...

The effect of desoxycorticosterone acetate (DCA) on the granulation tissue of healing and healed linear laparotomy wounds was studied in young adult male guinea pigs maintained on a complete diet and on a known intake of ascorbic acid. DCA induces the production of an excessive amount of granulation tissue, as evidenced by a relatively great number of fibroblasts and by a larger amount of groun...

P-glycoprotein (P-gp) is a membranous ATPase responsible for the multidrug resistance (MDR) phenotype. Using membrane vesicles prepared from the highly resistant cell line DC-3F/ADX we studied the influence of P-gp ATPase activity of four progesterone derivatives which specifically bind to P-gp and reverse MDR. Progesterone and desoxycorticosterone stimulate P-gp ATPase activity with, respectiv...

Desoxycorticosterone acetate prolongs the lives and restores many of the functions of patients suffering from Addison's disease and of adrenalectomized animals (1 to 5). The beneficial effects are related to the action on the kidneys which leads to excretion of potassium and retention of sodium (1, 5). Clinical observations have suggested that injurious results due to the steroid may appear alo...