AIn this study a simple and reliable stability-indicating RP-HPLC method was developed and validated for analysis of Dexpanthenol in an artificial tear formulation. The chromatographic separation was performed on a HPLC C18 column (25.0 cm  4.6 mm, 5 m) using a mixture of 0.037 M monobasic potassium phosphate in water (adjusted with 0.1% (v/v) phosphoric acid to a pH of 3.2) and methanol (90:...

AIn this study a simple and reliable stability-indicating RP-HPLC method was developed and validated for analysis of Dexpanthenol in an artificial tear formulation. The chromatographic separation was performed on a HPLC C18 column (25.0 cm  4.6 mm, 5 m) using a mixture of 0.037 M monobasic potassium phosphate in water (adjusted with 0.1% (v/v) phosphoric acid to a pH of 3.2) and methanol (90:...

Objective: The objective of this standardised experimental study was to investigate the antimicrobial efficacy of the combination of Axel Kramer Ojan Assadian chlorhexidine digluconate (CHX) and the anti-inflammatory pro-vitamin Torsten Koburger-Janssen dexpanthenol, which stimulates wound-healing, in the form of Bepanthen AntisepticWound Cream, in order to rule out possible antagonistic combin...

Dexpanthenol – a precursor to vitamin B5 is compound of natural origin that has long-known beneficial effect on skin and mucous membrane hydration epithelial healing. Its anti-inflammatory activity also used in treatment. effects superficial tissues have been observed numerous vitro vivo studies, but the exact mechanism action not yet understood. In ophthalmology, dexpanthenol well-known widely...

Impaired skin barrier plays a major role in the development of many diseases and conditions such as dry skin, sensitive atopic dermatitis, contact etc. The topical therapy aims at not only suppressing inflammatory response but also regenerating destroyed protective epidermal lipid dermatitis patients. Dexpanthenol was produced by synthesis middle last century is derivative pantothenic acid. Top...

Kidney damage due to ischemia-reperfusion injury (IRI) is a serious cause of morbidity and mortality. We induced an experimental kidney model in rats where intraperitoneal dexpanthenol were given compared controls terms oxidative stress, tubular damage, apoptosis, its effect on renal inflammation. Twelve-week-old male albino Wistar used for creating the study sample divided into three groups (n...

Objective: Oxidative stress is one of the main mechanisms epilepsy and depression. Based on our information, behavioral effects dexpanthenol in animals have not yet been demonstrated. Dexpanthenol itself a topical medicine to restore skin barrier against infections caused by microorganisms which also stimulates peristaltic movements gut when administered parenterally; however since it cheap eas...

Background: Considering the importance of treatment of sour nipples in breastfeeding mothers, the aim of this study was to evaluate the effect of dexpanthenol creams on the treatment of traumatic nipples. Materials and Methods: This study was a double-blinded, randomized, control trial, in which 82 postpartum mothers with nipple injuries who had attended health centers and Children’s Hospital ...

Poorly controlled diabetes mellitus would be harmful. Where abnormally high blood glucose level results in some serious complications such as diabetic wounds (1). The main concern with diabetic wounds is poor or delayed healing caused by peripheral arterial disease and peripheral neuropa-thy (2). In diabetic patient damage of blood vessels and impairment of immune system make ulcers difficult t...