OBJECTIVE Glycogen synthase kinase (GSK)-3beta plays an important role in cardiomyopathies. Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice were highly resistant to diabetes-induced cardiomyopathy. Therefore, we investigated whether metallothionein cardiac protection against diabetes is mediated by inactivation of GSK-3beta. RESEARCH DESIGN AND METHODS Diabetes was ind...

Pediatric cardiomyopathies are rare diseases with an annual incidence of 1.1 to 1.5 per 100 000. Dilated and hypertrophic cardiomyopathies are the most common; restrictive, noncompaction, and mixed cardiomyopathies occur infrequently; and arrhythmogenic right ventricular cardiomyopathy is rare. Pediatric cardiomyopathies can result from coronary artery abnormalities, tachyarrhythmias, exposure ...

A rare – or not so condition? Restrictive cardiomyopathies, caused by primary pathologies of the heart muscle, are considered diseases, corresponding to about 5% all cardiomyopathies. The most frequent form restrictive cardiomyopathy is cardiac amyloidosis (CA), which can be a benchmark since, with availability diagnostic technologies, its detection has been made much more frequent, associated ...

Correspondence to: Dr Siân E Hughes, Department of Histopathology, Royal Free and University College Medical School, University College London, UCL Hospitals NHS Trust, Rockefeller Building, University Street, London WC1E 6JJ, UK; [email protected] _________________________ C ardiomyopathies are defined as diseases of the myocardium, which cause cardiac dysfunction with heart failure, arrhy...